(22 nodes) (2022) Identification, Isolation, and Characterization of Melanocyte Precursor Cells in the Human Limbal Stroma. network (Capra hircus)

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Your Input:
	MITF	Melanocyte inducing transcription factor. (519 aa)
	TYR	Tyrosinase. (530 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (241 aa)
	DCT	Dopachrome tautomerase. (517 aa)
	MC1R	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Could be involved in spermatogenesis. (317 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (116 aa)
	SOX2	HMG box domain-containing protein. (320 aa)
	ABCB5	ATP binding cassette subfamily B member 5. (1250 aa)
	ITGA6	Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1072 aa)
	ACTB	Uncharacterized protein. (375 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	BCL2	BH4_2 domain-containing protein. (229 aa)
	ALB	Serum albumin. (608 aa)
	NGFR	Nerve growth factor receptor. (427 aa)
	SOX10	SRY-box transcription factor 10. (469 aa)
	CD63	Tetraspanin. (237 aa)
	POU5F1	POU domain protein. (360 aa)
	KIT	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (974 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	KITLG	Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (274 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	NES	Nestin; Belongs to the intermediate filament family. (1606 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB5	MITF	ENSCHIP00000009577	ENSCHIP00000025267	ATP binding cassette subfamily B member 5.	Melanocyte inducing transcription factor.	0.429
ABCB5	POU5F1	ENSCHIP00000009577	ENSCHIP00000023987	ATP binding cassette subfamily B member 5.	POU domain protein.	0.430
ABCB5	SOX2	ENSCHIP00000009577	ENSCHIP00000007702	ATP binding cassette subfamily B member 5.	HMG box domain-containing protein.	0.485
ABCB5	TYR	ENSCHIP00000009577	ENSCHIP00000002184	ATP binding cassette subfamily B member 5.	Tyrosinase.	0.525
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	BCL2	ENSCHIP00000011080	ENSCHIP00000015831	Uncharacterized protein.	BH4_2 domain-containing protein.	0.940
ACTB	CD63	ENSCHIP00000011080	ENSCHIP00000023741	Uncharacterized protein.	Tetraspanin.	0.795
ACTB	CTNNB1	ENSCHIP00000011080	ENSCHIP00000031016	Uncharacterized protein.	Catenin beta 1.	0.906
ACTB	CXCL12	ENSCHIP00000011080	ENSCHIP00000007530	Uncharacterized protein.	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.678
ACTB	CXCR4	ENSCHIP00000011080	ENSCHIP00000011766	Uncharacterized protein.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.759
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	ITGA6	ENSCHIP00000011080	ENSCHIP00000010556	Uncharacterized protein.	Integrin subunit alpha 6; Belongs to the integrin alpha chain family.	0.948
ACTB	KIT	ENSCHIP00000011080	ENSCHIP00000025751	Uncharacterized protein.	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	0.719
ACTB	KITLG	ENSCHIP00000011080	ENSCHIP00000030559	Uncharacterized protein.	Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family.	0.654
ACTB	MITF	ENSCHIP00000011080	ENSCHIP00000025267	Uncharacterized protein.	Melanocyte inducing transcription factor.	0.615
ACTB	NES	ENSCHIP00000011080	ENSCHIP00000032395	Uncharacterized protein.	Nestin; Belongs to the intermediate filament family.	0.800
ACTB	NGF	ENSCHIP00000011080	ENSCHIP00000003583	Uncharacterized protein.	Nerve growth factor; Belongs to the NGF-beta family.	0.780
ACTB	POU5F1	ENSCHIP00000011080	ENSCHIP00000023987	Uncharacterized protein.	POU domain protein.	0.794
ACTB	SOX10	ENSCHIP00000011080	ENSCHIP00000022016	Uncharacterized protein.	SRY-box transcription factor 10.	0.540
ACTB	SOX2	ENSCHIP00000011080	ENSCHIP00000007702	Uncharacterized protein.	HMG box domain-containing protein.	0.789