(11 nodes) (2022) CircRNA circ_0023984 promotes the progression of esophageal squamous cell carcinoma via regulating miR-134-5pcystatin-s axis. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HMGA2	Uncharacterized protein. (104 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (860 aa)
	NRIP1	Nuclear receptor interacting protein 1. (1156 aa)
	DAB2IP	DAB2 interacting protein. (1198 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	REV3L	REV3 like, DNA directed polymerase zeta catalytic subunit. (3134 aa)
	MMUT	Methylmalonyl-CoA mutase. (771 aa)
	NOX4	NADPH oxidase 4. (578 aa)
	YWHAZ	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide; Belongs to the 14-3-3 family. (245 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (397 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	CTNNB1	ENSCHIP00000006557	ENSCHIP00000031016	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Catenin beta 1.	0.568
AGO2	GAPDH	ENSCHIP00000006557	ENSCHIP00000025974	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Glyceraldehyde-3-phosphate dehydrogenase.	0.824
AGO2	HMGA2	ENSCHIP00000006557	ENSCHIP00000011914	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Uncharacterized protein.	0.495
AGO2	MMUT	ENSCHIP00000006557	ENSCHIP00000027222	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Methylmalonyl-CoA mutase.	0.905
CTNNB1	AGO2	ENSCHIP00000031016	ENSCHIP00000006557	Catenin beta 1.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.568
CTNNB1	GAPDH	ENSCHIP00000031016	ENSCHIP00000025974	Catenin beta 1.	Glyceraldehyde-3-phosphate dehydrogenase.	0.940
CTNNB1	HMGA2	ENSCHIP00000031016	ENSCHIP00000011914	Catenin beta 1.	Uncharacterized protein.	0.658
CTNNB1	MMUT	ENSCHIP00000031016	ENSCHIP00000027222	Catenin beta 1.	Methylmalonyl-CoA mutase.	0.779
CTNNB1	YWHAZ	ENSCHIP00000031016	ENSCHIP00000022145	Catenin beta 1.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide; Belongs to the 14-3-3 family.	0.882
GAPDH	AGO2	ENSCHIP00000025974	ENSCHIP00000006557	Glyceraldehyde-3-phosphate dehydrogenase.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.824
GAPDH	CTNNB1	ENSCHIP00000025974	ENSCHIP00000031016	Glyceraldehyde-3-phosphate dehydrogenase.	Catenin beta 1.	0.940
GAPDH	HMGA2	ENSCHIP00000025974	ENSCHIP00000011914	Glyceraldehyde-3-phosphate dehydrogenase.	Uncharacterized protein.	0.655
GAPDH	MMUT	ENSCHIP00000025974	ENSCHIP00000027222	Glyceraldehyde-3-phosphate dehydrogenase.	Methylmalonyl-CoA mutase.	0.908
GAPDH	NOX4	ENSCHIP00000025974	ENSCHIP00000024501	Glyceraldehyde-3-phosphate dehydrogenase.	NADPH oxidase 4.	0.753
GAPDH	YWHAZ	ENSCHIP00000025974	ENSCHIP00000022145	Glyceraldehyde-3-phosphate dehydrogenase.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide; Belongs to the 14-3-3 family.	0.788
HMGA2	AGO2	ENSCHIP00000011914	ENSCHIP00000006557	Uncharacterized protein.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.495
HMGA2	CTNNB1	ENSCHIP00000011914	ENSCHIP00000031016	Uncharacterized protein.	Catenin beta 1.	0.658
HMGA2	GAPDH	ENSCHIP00000011914	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.655
HMGA2	MMUT	ENSCHIP00000011914	ENSCHIP00000027222	Uncharacterized protein.	Methylmalonyl-CoA mutase.	0.613
MMUT	AGO2	ENSCHIP00000027222	ENSCHIP00000006557	Methylmalonyl-CoA mutase.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.905