(17 nodes) (2022) Proteomic Investigation Reveals Eukaryotic Translation Initiation Factor 5A Involvement in Porcine Reproductive and Respiratory Syndrome Virus Infection in vitro. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108634238	Interferon-induced transmembrane protein 3. (146 aa)
	STAT1	Signal transducer and activator of transcription. (834 aa)
	EIF4G1	Eukaryotic translation initiation factor 4 gamma 1. (1607 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
	ACTB	Uncharacterized protein. (375 aa)
	EIF4H	Eukaryotic translation initiation factor 4H. (214 aa)
	EIF5B	Eukaryotic translation initiation factor 5B. (1220 aa)
	LOC102180655	Uncharacterized protein. (146 aa)
	EIF5A	Eukaryotic translation initiation factor 5A. (154 aa)
	HNRNPA1	Uncharacterized protein. (320 aa)
	EIF4EBP1	Uncharacterized protein. (118 aa)
	EIF5A2	Eukaryotic translation initiation factor 5A. (153 aa)
	ISG15	Interferon-stimulated protein 17/ubiquitin cross-reactive protein. (157 aa)
	CD163	CD163 molecule. (1114 aa)
	IFIT3	Interferon induced protein with tetratricopeptide repeats 3. (492 aa)
	MX1	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (654 aa)
	EIF4E	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (217 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	CD163	ENSCHIP00000011080	ENSCHIP00000014907	Uncharacterized protein.	CD163 molecule.	0.670
ACTB	EIF4E	ENSCHIP00000011080	ENSCHIP00000005408	Uncharacterized protein.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.712
ACTB	EIF4EBP1	ENSCHIP00000011080	ENSCHIP00000020433	Uncharacterized protein.	Uncharacterized protein.	0.589
ACTB	HNRNPA1	ENSCHIP00000011080	ENSCHIP00000030443	Uncharacterized protein.	Uncharacterized protein.	0.567
ACTB	IFIT3	ENSCHIP00000011080	ENSCHIP00000012504	Uncharacterized protein.	Interferon induced protein with tetratricopeptide repeats 3.	0.463
ACTB	IL6	ENSCHIP00000011080	ENSCHIP00000009414	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.919
ACTB	ISG15	ENSCHIP00000011080	ENSCHIP00000017154	Uncharacterized protein.	Interferon-stimulated protein 17/ubiquitin cross-reactive protein.	0.722
ACTB	LOC102180655	ENSCHIP00000011080	ENSCHIP00000032744	Uncharacterized protein.	Uncharacterized protein.	0.406
ACTB	LOC108634238	ENSCHIP00000011080	ENSCHIP00000003572	Uncharacterized protein.	Interferon-induced transmembrane protein 3.	0.406
ACTB	MX1	ENSCHIP00000011080	ENSCHIP00000001236	Uncharacterized protein.	MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.720
ACTB	STAT1	ENSCHIP00000011080	ENSCHIP00000005767	Uncharacterized protein.	Signal transducer and activator of transcription.	0.838
CD163	ACTB	ENSCHIP00000014907	ENSCHIP00000011080	CD163 molecule.	Uncharacterized protein.	0.670
CD163	IL6	ENSCHIP00000014907	ENSCHIP00000009414	CD163 molecule.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.905
CD163	STAT1	ENSCHIP00000014907	ENSCHIP00000005767	CD163 molecule.	Signal transducer and activator of transcription.	0.627
EIF4E	ACTB	ENSCHIP00000005408	ENSCHIP00000011080	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	Uncharacterized protein.	0.712
EIF4E	EIF4EBP1	ENSCHIP00000005408	ENSCHIP00000020433	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	Uncharacterized protein.	0.999
EIF4E	EIF4G1	ENSCHIP00000005408	ENSCHIP00000005945	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	Eukaryotic translation initiation factor 4 gamma 1.	0.999
EIF4E	EIF4H	ENSCHIP00000005408	ENSCHIP00000022805	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	Eukaryotic translation initiation factor 4H.	0.775
EIF4E	EIF5B	ENSCHIP00000005408	ENSCHIP00000033655	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	Eukaryotic translation initiation factor 5B.	0.644
EIF4E	HNRNPA1	ENSCHIP00000005408	ENSCHIP00000030443	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	Uncharacterized protein.	0.593