46 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TYK2	Tyrosine-protein kinase. (1186 aa)
	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. (128 aa)
	CD151	Tetraspanin. (253 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (446 aa)
	CD81	Tetraspanin. (236 aa)
	STAT1	Signal transducer and activator of transcription. (834 aa)
	HSP90B1	Heat shock protein 90 beta family member 1. (836 aa)
	PDC	Phosducin. (245 aa)
	TMPRSS3	Transmembrane serine protease 3; Belongs to the peptidase S1 family. (453 aa)
	PIGL	Phosphatidylinositol glycan anchor biosynthesis class L. (253 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	JAK1	Tyrosine-protein kinase. (1159 aa)
	RALA	RAS like proto-oncogene A. (206 aa)
	PIGO	Phosphatidylinositol glycan anchor biosynthesis class O. (1131 aa)
	GPAA1	Glycosylphosphatidylinositol anchor attachment 1. (617 aa)
	MAVS	Mitochondrial antiviral signaling protein. (522 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (918 aa)
	IRF9	Interferon regulatory factor 9. (470 aa)
	STAT2	Signal transducer and activator of transcription. (851 aa)
	B3GAT3	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (335 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
	B4GALT7	Beta-1,4-galactosyltransferase 7. (327 aa)
	IFNAR1	Interferon alpha and beta receptor subunit 1. (560 aa)
	SLC35B2	Solute carrier family 35 member B2. (437 aa)
	PIGA	Phosphatidylinositol glycan anchor biosynthesis class A. (490 aa)
	ALB	Serum albumin. (608 aa)
	RALB	RAS like proto-oncogene B. (206 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (954 aa)
	IFIH1	Interferon induced with helicase C domain 1. (1023 aa)
	IL10RB	Interleukin 10 receptor subunit beta. (317 aa)
	OLIG1	Oligodendrocyte transcription factor 1. (259 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	TLR7	TIR domain-containing protein. (1054 aa)
	PIGT	Phosphatidylinositol glycan anchor biosynthesis class T. (578 aa)
	RRP1B	Ribosomal RNA processing 1B. (735 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	NBEAL2	Neurobeachin like 2. (2753 aa)
	TMEM30A	Cell cycle control protein; Belongs to the CDC50/LEM3 family. (361 aa)
	FNDC3B	Fibronectin type III domain containing 3B. (1207 aa)
	IFNLR1	Interferon lambda receptor 1. (523 aa)
	TLR9	TIR domain-containing protein. (1070 aa)
	NOD2	Uncharacterized protein. (982 aa)
	RALGAPB	Ral GTPase activating protein non-catalytic beta subunit. (1512 aa)
	IYD	Iodotyrosine deiodinase. (313 aa)
	UNC93B1	Unc-93 homolog B1, TLR signaling regulator. (600 aa)
	PGAP2	Post-GPI attachment to proteins 2. (255 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	CD81	ENSCHIP00000020234	ENSCHIP00000005620	Serum albumin.	Tetraspanin.	0.720
ALB	GAPDH	ENSCHIP00000020234	ENSCHIP00000025974	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.948
ALB	HSP90B1	ENSCHIP00000020234	ENSCHIP00000005878	Serum albumin.	Heat shock protein 90 beta family member 1.	0.458
ALB	IFIH1	ENSCHIP00000020234	ENSCHIP00000021583	Serum albumin.	Interferon induced with helicase C domain 1.	0.426
ALB	IFNAR1	ENSCHIP00000020234	ENSCHIP00000018710	Serum albumin.	Interferon alpha and beta receptor subunit 1.	0.476
ALB	IFNG	ENSCHIP00000020234	ENSCHIP00000016152	Serum albumin.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.893
ALB	IL18	ENSCHIP00000020234	ENSCHIP00000023420	Serum albumin.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.727
ALB	JAK1	ENSCHIP00000020234	ENSCHIP00000010087	Serum albumin.	Tyrosine-protein kinase.	0.547
ALB	MAVS	ENSCHIP00000020234	ENSCHIP00000014830	Serum albumin.	Mitochondrial antiviral signaling protein.	0.495
ALB	NOD2	ENSCHIP00000020234	ENSCHIP00000029729	Serum albumin.	Uncharacterized protein.	0.423
ALB	STAT1	ENSCHIP00000020234	ENSCHIP00000005767	Serum albumin.	Signal transducer and activator of transcription.	0.727
ALB	STAT2	ENSCHIP00000020234	ENSCHIP00000015412	Serum albumin.	Signal transducer and activator of transcription.	0.624
ALB	TGFB1	ENSCHIP00000020234	ENSCHIP00000008885	Serum albumin.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.854
ALB	TLR3	ENSCHIP00000020234	ENSCHIP00000015102	Serum albumin.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.660
ALB	TLR7	ENSCHIP00000020234	ENSCHIP00000023443	Serum albumin.	TIR domain-containing protein.	0.649
ALB	TLR9	ENSCHIP00000020234	ENSCHIP00000029061	Serum albumin.	TIR domain-containing protein.	0.658
B3GAT3	B4GALT7	ENSCHIP00000015873	ENSCHIP00000018482	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	Beta-1,4-galactosyltransferase 7.	0.880
B3GAT3	EXT1	ENSCHIP00000015873	ENSCHIP00000005221	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family.	0.800
B3GAT3	PIGL	ENSCHIP00000015873	ENSCHIP00000007763	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	Phosphatidylinositol glycan anchor biosynthesis class L.	0.445
B3GAT3	SLC35B2	ENSCHIP00000015873	ENSCHIP00000018750	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.	Solute carrier family 35 member B2.	0.889