11 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
	CDK2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	ACTB	Uncharacterized protein. (375 aa)
	PXDN	Peroxidasin. (1525 aa)
	TTN	Uncharacterized protein. (2149 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	SQLE	Squalene epoxidase. (572 aa)
	CTNNB1	Catenin beta 1. (781 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	CCND1	ENSCHIP00000011080	ENSCHIP00000006815	Uncharacterized protein.	Cyclin D1; Belongs to the cyclin family.	0.890
ACTB	CDK2	ENSCHIP00000011080	ENSCHIP00000003142	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.838
ACTB	CTNNB1	ENSCHIP00000011080	ENSCHIP00000031016	Uncharacterized protein.	Catenin beta 1.	0.906
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	JUN	ENSCHIP00000011080	ENSCHIP00000001903	Uncharacterized protein.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.681
ACTB	PXDN	ENSCHIP00000011080	ENSCHIP00000015493	Uncharacterized protein.	Peroxidasin.	0.962
ACTB	TP53	ENSCHIP00000011080	ENSCHIP00000030141	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.907
ACTB	TTN	ENSCHIP00000011080	ENSCHIP00000015886	Uncharacterized protein.	Uncharacterized protein.	0.400
CCND1	ACTB	ENSCHIP00000006815	ENSCHIP00000011080	Cyclin D1; Belongs to the cyclin family.	Uncharacterized protein.	0.890
CCND1	CDK2	ENSCHIP00000006815	ENSCHIP00000003142	Cyclin D1; Belongs to the cyclin family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.995
CCND1	CTNNB1	ENSCHIP00000006815	ENSCHIP00000031016	Cyclin D1; Belongs to the cyclin family.	Catenin beta 1.	0.934
CCND1	GAPDH	ENSCHIP00000006815	ENSCHIP00000025974	Cyclin D1; Belongs to the cyclin family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.915
CCND1	JUN	ENSCHIP00000006815	ENSCHIP00000001903	Cyclin D1; Belongs to the cyclin family.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.765
CCND1	PCNA	ENSCHIP00000006815	ENSCHIP00000015091	Cyclin D1; Belongs to the cyclin family.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.963
CCND1	PXDN	ENSCHIP00000006815	ENSCHIP00000015493	Cyclin D1; Belongs to the cyclin family.	Peroxidasin.	0.857
CCND1	TP53	ENSCHIP00000006815	ENSCHIP00000030141	Cyclin D1; Belongs to the cyclin family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.901
CDK2	ACTB	ENSCHIP00000003142	ENSCHIP00000011080	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.838
CDK2	CCND1	ENSCHIP00000003142	ENSCHIP00000006815	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cyclin D1; Belongs to the cyclin family.	0.995
CDK2	CTNNB1	ENSCHIP00000003142	ENSCHIP00000031016	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Catenin beta 1.	0.687
CDK2	GAPDH	ENSCHIP00000003142	ENSCHIP00000025974	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Glyceraldehyde-3-phosphate dehydrogenase.	0.851