31 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGF21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	HSPA5	Heat shock 70kDa protein 5; Belongs to the heat shock protein 70 family. (655 aa)
	NPPA	Natriuretic peptide A. (188 aa)
	PCK2	Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
	XBP1	BZIP domain-containing protein. (261 aa)
	CLPP	ATP-dependent Clp protease proteolytic subunit. (272 aa)
	NOX4	NADPH oxidase 4. (578 aa)
	MIOX	Myo-inositol oxygenase. (285 aa)
	MTHFD2	Uncharacterized protein. (352 aa)
	SCD	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid ox [...] (359 aa)
	RARS1	Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (660 aa)
	TRIB3	Tribbles pseudokinase 3. (357 aa)
	DNAJB9	DnaJ heat shock protein family (Hsp40) member B9. (223 aa)
	ALDH1L2	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (923 aa)
	SLC20A1	Phosphate transporter; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. (681 aa)
	PBRM1	Polybromo 1. (1633 aa)
	ATF6	Activating transcription factor 6. (664 aa)
	CHAC1	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (260 aa)
	ATF5	Activating transcription factor 5. (287 aa)
	HIF1A	Uncharacterized protein. (823 aa)
	ATF3	Activating transcription factor 3. (181 aa)
	CPT1A	Carnitine O-palmitoyltransferase 1; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
	SIRT3	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (333 aa)
	ATF4	Activating transcription factor 4. (352 aa)
	ASNS	Asparagine synthetase [glutamine-hydrolyzing]. (561 aa)
	ACTB	Uncharacterized protein. (375 aa)
	KEAP1	Kelch like ECH associated protein 1. (624 aa)
	DDIT4	DNA damage inducible transcript 4. (229 aa)
	ALDH18A1	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (825 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (502 aa)
	SERP1	Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (66 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ATF3	ENSCHIP00000011080	ENSCHIP00000014267	Uncharacterized protein.	Activating transcription factor 3.	0.608
ACTB	ATF4	ENSCHIP00000011080	ENSCHIP00000013483	Uncharacterized protein.	Activating transcription factor 4.	0.683
ACTB	ATF6	ENSCHIP00000011080	ENSCHIP00000019493	Uncharacterized protein.	Activating transcription factor 6.	0.774
ACTB	CPT1A	ENSCHIP00000011080	ENSCHIP00000014243	Uncharacterized protein.	Carnitine O-palmitoyltransferase 1; Belongs to the carnitine/choline acetyltransferase family.	0.589
ACTB	FGF21	ENSCHIP00000011080	ENSCHIP00000030527	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.608
ACTB	HIF1A	ENSCHIP00000011080	ENSCHIP00000014770	Uncharacterized protein.	Uncharacterized protein.	0.856
ACTB	HSPA5	ENSCHIP00000011080	ENSCHIP00000030268	Uncharacterized protein.	Heat shock 70kDa protein 5; Belongs to the heat shock protein 70 family.	0.713
ACTB	KEAP1	ENSCHIP00000011080	ENSCHIP00000009131	Uncharacterized protein.	Kelch like ECH associated protein 1.	0.780
ACTB	NOX4	ENSCHIP00000011080	ENSCHIP00000024501	Uncharacterized protein.	NADPH oxidase 4.	0.778
ACTB	NPPA	ENSCHIP00000011080	ENSCHIP00000029669	Uncharacterized protein.	Natriuretic peptide A.	0.500
ACTB	PBRM1	ENSCHIP00000011080	ENSCHIP00000019609	Uncharacterized protein.	Polybromo 1.	0.892
ACTB	SCD	ENSCHIP00000011080	ENSCHIP00000023844	Uncharacterized protein.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (By similarity). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid ox [...]	0.580
ACTB	SIRT3	ENSCHIP00000011080	ENSCHIP00000014223	Uncharacterized protein.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.670
ACTB	TRIB3	ENSCHIP00000011080	ENSCHIP00000022310	Uncharacterized protein.	Tribbles pseudokinase 3.	0.408
ACTB	XBP1	ENSCHIP00000011080	ENSCHIP00000027960	Uncharacterized protein.	BZIP domain-containing protein.	0.770
ALDH18A1	ALDH1L2	ENSCHIP00000005149	ENSCHIP00000021223	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.746
ALDH18A1	ASNS	ENSCHIP00000005149	ENSCHIP00000012001	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Asparagine synthetase [glutamine-hydrolyzing].	0.743
ALDH18A1	MTHFD2	ENSCHIP00000005149	ENSCHIP00000024076	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Uncharacterized protein.	0.721
ALDH18A1	SHMT2	ENSCHIP00000005149	ENSCHIP00000001693	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.706
ALDH1L2	ALDH18A1	ENSCHIP00000021223	ENSCHIP00000005149	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	0.746