STRINGSTRING
FRK FRK CD34 CD34 YES1 YES1 CSF2 CSF2 CSF1R CSF1R STAT6 STAT6 KITLG KITLG IL1B IL1B CD40 CD40 CD68 CD68 EPCAM EPCAM GAPDH GAPDH LYN LYN LOC108638461 LOC108638461 LOC108638467 LOC108638467 CXCL9 CXCL9 LOC102190602 LOC102190602 LOC108633178 LOC108633178 LOC102176598 LOC102176598 STAT3 STAT3 TIGIT TIGIT IL13 IL13 IL4 IL4 CCR7 CCR7 TLR4 TLR4 LOC102177285 LOC102177285 LOC102190507 LOC102190507 IL10 IL10 IFNG IFNG LOC102168343 LOC102168343 LOC102175759 LOC102175759 CD163 CD163 PIK3C3 PIK3C3 FGR FGR CXCL10 CXCL10 CXCR3 CXCR3 LOC102176878 LOC102176878 FOXP3 FOXP3 LCK LCK CASP3 CASP3 VSIG4 VSIG4 RAG1 RAG1 TGFB1 TGFB1 CXCL12 CXCL12 PIK3CG PIK3CG CD4 CD4 PDCD1 PDCD1 XCR1 XCR1 FYN FYN CTLA4 CTLA4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FRKTyrosine-protein kinase. (515 aa)
CD34Uncharacterized protein. (384 aa)
YES1Tyrosine-protein kinase. (541 aa)
CSF2Granulocyte-macrophage colony stimulating factor. (144 aa)
CSF1RColony stimulating factor 1 receptor. (958 aa)
STAT6Signal transducer and activator of transcription. (841 aa)
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (274 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
CD40CD40 molecule. (280 aa)
CD68CD68 molecule. (335 aa)
EPCAMEpithelial cell adhesion molecule. (314 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
LYNTyrosine-protein kinase. (512 aa)
LOC108638461Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (251 aa)
LOC108638467Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
CXCL9C-X-C motif chemokine. (125 aa)
LOC102190602Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (251 aa)
LOC108633178Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (246 aa)
LOC102176598Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (250 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
TIGITT cell immunoreceptor with Ig and ITIM domains. (277 aa)
IL13Interleukin 13. (131 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
LOC102177285Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (246 aa)
LOC102190507Uncharacterized protein. (139 aa)
IL10Interleukin 10. (177 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
LOC102168343Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (256 aa)
LOC102175759Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (254 aa)
CD163CD163 molecule. (1114 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (900 aa)
FGRTyrosine-protein kinase. (527 aa)
CXCL10C-X-C motif chemokine. (102 aa)
CXCR3C-X-C chemokine receptor type 3; Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity). (367 aa)
LOC102176878Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (251 aa)
FOXP3Forkhead box P3. (463 aa)
LCKTyrosine-protein kinase. (509 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (275 aa)
VSIG4V-set and immunoglobulin domain containing 4. (352 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (116 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
CD4CD4 molecule. (455 aa)
PDCD1Ig-like domain-containing protein. (280 aa)
XCR1X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
FYNTyrosine-protein kinase. (537 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (221 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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