STRINGSTRING
TP53 TP53 B3GALT5 B3GALT5 COMT COMT LOC102176799 LOC102176799 CD81 CD81 GAPDHS GAPDHS RXRB RXRB THRA THRA LOC102181016 LOC102181016 GOT2 GOT2 TSG101 TSG101 DDC DDC ESR1 ESR1 IKBKB IKBKB INPPL1 INPPL1 PIK3C3 PIK3C3 REN REN VAV3 VAV3 THBS2 THBS2 CD79B CD79B ENSCHIP00000017192 ENSCHIP00000017192 LDH-A LDH-A BRAF BRAF LAMA4 LAMA4 EGFR EGFR ST3GAL1 ST3GAL1 GAPDH GAPDH GOT1 GOT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
B3GALT5Hexosyltransferase. (311 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (272 aa)
LOC102176799Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
CD81Tetraspanin. (236 aa)
GAPDHSGlyceraldehyde-3-phosphate dehydrogenase. (385 aa)
RXRBRetinoid X receptor beta. (533 aa)
THRAThyroid hormone receptor alpha. (511 aa)
LOC102181016Gp_dh_N domain-containing protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (318 aa)
GOT2Aspartate aminotransferase. (430 aa)
TSG101Uncharacterized protein. (391 aa)
DDCDopa decarboxylase. (519 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1264 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (900 aa)
RENRenin; Belongs to the peptidase A1 family. (403 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
THBS2Thrombospondin 2. (1181 aa)
CD79BCD79b molecule. (221 aa)
ENSCHIP00000017192Uncharacterized protein. (295 aa)
LDH-AL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (774 aa)
LAMA4Laminin subunit alpha 4. (1824 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
ST3GAL1ST3 beta-galactoside alpha-2,3-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (339 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
GOT1Aspartate aminotransferase. (413 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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