STRINGSTRING
IL1A IL1A CXCL12 CXCL12 CXCL5 CXCL5 TJP2 TJP2 TNF TNF OCLN OCLN TJP1 TJP1 IL10 IL10 CCL5 CCL5 IFNG IFNG ACE2 ACE2 IL1B IL1B PXDN PXDN CCL20 CCL20 CXCL10 CXCL10 LOC102182683 LOC102182683 ACTB ACTB IL7 IL7 CCL2 CCL2 CCL11 CCL11 IL6 IL6 GAPDH GAPDH CXCL9 CXCL9 IL34 IL34 CLDN5 CLDN5 MTOR MTOR CXCL16 CXCL16 ALB ALB CXCL11 CXCL11 IL15 IL15 TMPRSS2 TMPRSS2 IL2 IL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (254 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (116 aa)
CXCL5C-X-C motif chemokine. (119 aa)
TJP2Uncharacterized protein; Belongs to the MAGUK family. (1151 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1766 aa)
IL10Interleukin 10. (177 aa)
CCL5C-C motif chemokine. (91 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
ACE2Angiotensin-converting enzyme. (804 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
PXDNPeroxidasin. (1525 aa)
CCL20C-C motif chemokine. (96 aa)
CXCL10C-X-C motif chemokine. (102 aa)
LOC102182683C-X-C motif chemokine. (109 aa)
ACTBUncharacterized protein. (375 aa)
IL7Interleukin 7. (181 aa)
CCL2C-C motif chemokine. (98 aa)
CCL11C-C motif chemokine. (97 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
CXCL9C-X-C motif chemokine. (125 aa)
IL34Interleukin 34. (233 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
CXCL16Uncharacterized protein. (252 aa)
ALBSerum albumin. (608 aa)
CXCL11C-X-C motif chemokine. (87 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (161 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (492 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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