(9 nodes) (2022) Host HSPD1 Translocation from Mitochondria to the Cytoplasm Induced by Streptococcus suis Serovar 2 Enolase Mediates Apoptosis and Loss of Blood-Brain Barrier Integrity. network (Capra hircus)

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second shell of interactors

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Known Interactions

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Predicted Interactions

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Your Input:
	EIF4E	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
	LOC102175427	Uncharacterized protein. (246 aa)
	RPSA	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteri [...] (294 aa)
	ACTB	Uncharacterized protein. (375 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
	CLDN5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	PTS	6-pyruvoyl tetrahydrobiopterin synthase. (145 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	CASP3	ENSCHIP00000011080	ENSCHIP00000011490	Uncharacterized protein.	Caspase 3; Belongs to the peptidase C14A family.	0.996
ACTB	CLDN5	ENSCHIP00000011080	ENSCHIP00000022107	Uncharacterized protein.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.775
ACTB	EIF4E	ENSCHIP00000011080	ENSCHIP00000005408	Uncharacterized protein.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.712
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	RPSA	ENSCHIP00000011080	ENSCHIP00000008913	Uncharacterized protein.	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteri [...]	0.493
ACTB	TLR4	ENSCHIP00000011080	ENSCHIP00000019512	Uncharacterized protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.879
CASP3	ACTB	ENSCHIP00000011490	ENSCHIP00000011080	Caspase 3; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.996
CASP3	CLDN5	ENSCHIP00000011490	ENSCHIP00000022107	Caspase 3; Belongs to the peptidase C14A family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.577
CASP3	EIF4E	ENSCHIP00000011490	ENSCHIP00000005408	Caspase 3; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.578
CASP3	GAPDH	ENSCHIP00000011490	ENSCHIP00000025974	Caspase 3; Belongs to the peptidase C14A family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.943
CASP3	TLR4	ENSCHIP00000011490	ENSCHIP00000019512	Caspase 3; Belongs to the peptidase C14A family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.796
CLDN5	ACTB	ENSCHIP00000022107	ENSCHIP00000011080	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.775
CLDN5	CASP3	ENSCHIP00000022107	ENSCHIP00000011490	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Caspase 3; Belongs to the peptidase C14A family.	0.577
CLDN5	GAPDH	ENSCHIP00000022107	ENSCHIP00000025974	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.718
CLDN5	TLR4	ENSCHIP00000022107	ENSCHIP00000019512	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.427
EIF4E	ACTB	ENSCHIP00000005408	ENSCHIP00000011080	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	Uncharacterized protein.	0.712
EIF4E	CASP3	ENSCHIP00000005408	ENSCHIP00000011490	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	Caspase 3; Belongs to the peptidase C14A family.	0.578
EIF4E	GAPDH	ENSCHIP00000005408	ENSCHIP00000025974	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.712
GAPDH	ACTB	ENSCHIP00000025974	ENSCHIP00000011080	Glyceraldehyde-3-phosphate dehydrogenase.	Uncharacterized protein.	0.979
GAPDH	CASP3	ENSCHIP00000025974	ENSCHIP00000011490	Glyceraldehyde-3-phosphate dehydrogenase.	Caspase 3; Belongs to the peptidase C14A family.	0.943