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LOC102189503 LOC102189503 NDUFAF3 NDUFAF3 POLR2D POLR2D LOC102173997 LOC102173997 COX8A COX8A GFAP GFAP POLR2G POLR2G WDR5 WDR5 ATP5F1E ATP5F1E TOMM40 TOMM40 COX6B1 COX6B1 POLR2L POLR2L ERCC4 ERCC4 ND2 ND2 COX1 COX1 COX2 COX2 ATP8 ATP8 ATP6 ATP6 CYTB CYTB POLR2M POLR2M LOC102191748 LOC102191748 LOC102185882 LOC102185882 LOC102180307 LOC102180307 PRDM11 PRDM11 TIMM13 TIMM13 TIMM50 TIMM50 LOC108633554 LOC108633554 LOC102182848 LOC102182848 POLR2H POLR2H CACNA1B CACNA1B COX14 COX14 LOC108636012 LOC108636012 H3-4 H3-4 LOC108634231 LOC108634231 LOC108638252 LOC108638252 POLR2J POLR2J RFC2 RFC2 NDUFA7 NDUFA7 TIMM8B TIMM8B LOC102172954 LOC102172954 KMT5C KMT5C LOC102191741 LOC102191741 LOC102180554 LOC102180554 ATP5MC2 ATP5MC2 LOC106503499 LOC106503499 LOC106503502 LOC106503502 LOC108633916 LOC108633916 LOC108636047 LOC108636047 LOC106503503 LOC106503503 ATP5F1B ATP5F1B PRMT2 PRMT2 COX19 COX19 CASP7 CASP7 PYGM PYGM LOC102171353 LOC102171353 LOC102169981 LOC102169981 CHRNB4 CHRNB4 POLR2C POLR2C ATP5PB ATP5PB ENSCHIP00000009386 ENSCHIP00000009386 POLR2K POLR2K POLR2F POLR2F ACTB ACTB NDUFB7 NDUFB7 POLR2E POLR2E RBBP5 RBBP5 COX7A2L COX7A2L ATP5F1A ATP5F1A ATF4 ATF4 KMT2D KMT2D TIMM22 TIMM22 COX5B COX5B ATP5MC1 ATP5MC1 CACNA1A CACNA1A SCN3A SCN3A KDM6B KDM6B UQCRQ UQCRQ KCND2 KCND2 CACNA1H CACNA1H ATP5MC3 ATP5MC3 ATP5F1C ATP5F1C HDAC4 HDAC4 ALB ALB COX6B2 COX6B2 SIRT2 SIRT2 NDUFA11 NDUFA11 ASH2L ASH2L DPY30 DPY30 ATP5MF ATP5MF CUL4B CUL4B SCN11A SCN11A ATP5PF ATP5PF ATP5F1D ATP5F1D NDUFAF2 NDUFAF2 PYGL PYGL TOMM22 TOMM22 KDM6A KDM6A SCN2B SCN2B LOC106501717 LOC106501717 PYGB PYGB ATP5PD ATP5PD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
LOC102189503Histone H3; Belongs to the histone H3 family. (136 aa)
NDUFAF3NADH:ubiquinone oxidoreductase complex assembly factor 3. (184 aa)
POLR2DRNA polymerase II subunit D. (142 aa)
LOC102173997Capra hircus breed Kapro cytochrome c mRNA; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
COX8ACytochrome c oxidase subunit 8A. (69 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (428 aa)
POLR2GRNA polymerase II subunit G. (189 aa)
WDR5WD repeat domain 5. (334 aa)
ATP5F1EUncharacterized protein. (51 aa)
TOMM40Translocase of outer mitochondrial membrane 40. (361 aa)
COX6B1Cytochrome c oxidase subunit 6B1. (99 aa)
POLR2LRNA polymerase II subunit L. (67 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
ND2NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). (347 aa)
COX1Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (514 aa)
COX2Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] (227 aa)
ATP8ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (65 aa)
ATP6ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (226 aa)
CYTBCytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (379 aa)
POLR2MRNA polymerase II subunit M. (370 aa)
LOC102191748Histone domain-containing protein. (136 aa)
LOC102185882Histone H3; Belongs to the histone H3 family. (136 aa)
LOC102180307Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
PRDM11PR/SET domain 11. (1234 aa)
TIMM13Translocase of inner mitochondrial membrane 13; Belongs to the small Tim family. (95 aa)
TIMM50Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (355 aa)
LOC108633554Histone domain-containing protein. (136 aa)
LOC102182848Histone H3; Belongs to the histone H3 family. (136 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2358 aa)
COX14Cytochrome c oxidase assembly factor COX14. (57 aa)
LOC108636012Histone H3; Belongs to the histone H3 family. (136 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108634231Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108638252ATP synthase subunit; Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proto [...] (103 aa)
POLR2JRNA_pol_L_2 domain-containing protein. (136 aa)
RFC2Replication factor C subunit 2. (352 aa)
NDUFA7Uncharacterized protein. (126 aa)
TIMM8BTranslocase of inner mitochondrial membrane 8 homolog B; Belongs to the small Tim family. (83 aa)
LOC102172954Histone H4. (103 aa)
KMT5CLysine methyltransferase 5C. (455 aa)
LOC102191741Uncharacterized protein. (152 aa)
LOC102180554Histone H3; Belongs to the histone H3 family. (136 aa)
ATP5MC2ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (143 aa)
LOC106503499Histone H3; Belongs to the histone H3 family. (136 aa)
LOC106503502Histone H4. (103 aa)
LOC108633916Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108636047Histone H4. (103 aa)
LOC106503503Histone H4. (103 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
PRMT2Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (434 aa)
COX19Cytochrome c oxidase assembly factor COX19. (89 aa)
CASP7Caspase 7; Belongs to the peptidase C14A family. (301 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (857 aa)
LOC102171353Histone H3; Belongs to the histone H3 family. (136 aa)
LOC102169981Histone domain-containing protein. (136 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (496 aa)
POLR2CRNA polymerase II subunit C. (275 aa)
ATP5PBATP synthase peripheral stalk-membrane subunit b. (256 aa)
ENSCHIP00000009386Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (102 aa)
POLR2KUncharacterized protein. (58 aa)
POLR2FRNA polymerase II subunit F. (127 aa)
ACTBUncharacterized protein. (375 aa)
NDUFB7NADH:ubiquinone oxidoreductase subunit B7. (137 aa)
POLR2ERNA polymerase II subunit E. (210 aa)
RBBP5RB binding protein 5, histone lysine methyltransferase complex subunit. (538 aa)
COX7A2LCytochrome c oxidase subunit 7A2 like. (114 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (560 aa)
ATF4Activating transcription factor 4. (352 aa)
KMT2DLysine methyltransferase 2D. (5491 aa)
TIMM22Translocase of inner mitochondrial membrane 22. (194 aa)
COX5BCytochrome c oxidase subunit 5B. (143 aa)
ATP5MC1ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (136 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2487 aa)
SCN3ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2008 aa)
KDM6BLysine demethylase 6B. (1685 aa)
UQCRQUbiquinol-cytochrome c reductase complex III subunit VII. (82 aa)
KCND2Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (397 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (1453 aa)
ATP5MC3ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family. (141 aa)
ATP5F1CATP synthase subunit gamma. (298 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
ALBSerum albumin. (608 aa)
COX6B2Cytochrome c oxidase subunit; Belongs to the cytochrome c oxidase subunit 6B. (88 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (390 aa)
NDUFA11Uncharacterized protein. (141 aa)
ASH2LASH2 like, histone lysine methyltransferase complex subunit. (635 aa)
DPY30Uncharacterized protein. (99 aa)
ATP5MFUncharacterized protein. (104 aa)
CUL4BCullin 4B; Belongs to the cullin family. (1027 aa)
SCN11ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1780 aa)
ATP5PFATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain; Belongs to the eukaryotic ATPase subunit F6 family. (108 aa)
ATP5F1DATP synthase F1 subunit delta. (168 aa)
NDUFAF2Uncharacterized protein. (168 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (851 aa)
TOMM22Translocase of outer mitochondrial membrane 22. (142 aa)
KDM6ALysine demethylase 6A. (1386 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (215 aa)
LOC106501717Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (846 aa)
ATP5PDATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (162 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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