23 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
	GOT1	Aspartate aminotransferase. (413 aa)
	ACSL1	Acyl-CoA synthetase long chain family member 1. (719 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	AASDH	Aminoadipate-semialdehyde dehydrogenase. (1106 aa)
	FADS1	Fatty acid desaturase 1. (453 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (488 aa)
	FASN	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2755 aa)
	MPO	Uncharacterized protein. (729 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	HIF1A	Uncharacterized protein. (823 aa)
	FADS2	Fatty acid desaturase 2. (444 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	CASP1	Uncharacterized protein; Belongs to the peptidase C14A family. (411 aa)
	ACTB	Uncharacterized protein. (375 aa)
	GOT2	Aspartate aminotransferase. (430 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (275 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (452 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
	CDK2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AASDH	ACSL1	ENSCHIP00000025675	ENSCHIP00000026081	Aminoadipate-semialdehyde dehydrogenase.	Acyl-CoA synthetase long chain family member 1.	0.766
AASDH	FADS2	ENSCHIP00000025675	ENSCHIP00000014470	Aminoadipate-semialdehyde dehydrogenase.	Fatty acid desaturase 2.	0.437
AASDH	FASN	ENSCHIP00000025675	ENSCHIP00000019407	Aminoadipate-semialdehyde dehydrogenase.	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	0.977
AASDH	GOT2	ENSCHIP00000025675	ENSCHIP00000010968	Aminoadipate-semialdehyde dehydrogenase.	Aspartate aminotransferase.	0.482
AASDH	PPARG	ENSCHIP00000025675	ENSCHIP00000015163	Aminoadipate-semialdehyde dehydrogenase.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.424
ACSL1	AASDH	ENSCHIP00000026081	ENSCHIP00000025675	Acyl-CoA synthetase long chain family member 1.	Aminoadipate-semialdehyde dehydrogenase.	0.766
ACSL1	FADS1	ENSCHIP00000026081	ENSCHIP00000025629	Acyl-CoA synthetase long chain family member 1.	Fatty acid desaturase 1.	0.422
ACSL1	FADS2	ENSCHIP00000026081	ENSCHIP00000014470	Acyl-CoA synthetase long chain family member 1.	Fatty acid desaturase 2.	0.526
ACSL1	FASN	ENSCHIP00000026081	ENSCHIP00000019407	Acyl-CoA synthetase long chain family member 1.	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	0.982
ACSL1	PPARG	ENSCHIP00000026081	ENSCHIP00000015163	Acyl-CoA synthetase long chain family member 1.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.763
ACTB	CASP1	ENSCHIP00000011080	ENSCHIP00000011226	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.857
ACTB	CASP3	ENSCHIP00000011080	ENSCHIP00000011490	Uncharacterized protein.	Caspase 3; Belongs to the peptidase C14A family.	0.996
ACTB	CASP6	ENSCHIP00000011080	ENSCHIP00000008928	Uncharacterized protein.	Caspase 6; Belongs to the peptidase C14A family.	0.960
ACTB	CASP8	ENSCHIP00000011080	ENSCHIP00000020513	Uncharacterized protein.	Caspase 8; Belongs to the peptidase C14A family.	0.867
ACTB	CASP9	ENSCHIP00000011080	ENSCHIP00000008590	Uncharacterized protein.	Caspase 9; Belongs to the peptidase C14A family.	0.891
ACTB	CCND1	ENSCHIP00000011080	ENSCHIP00000006815	Uncharacterized protein.	Cyclin D1; Belongs to the cyclin family.	0.890
ACTB	CDK2	ENSCHIP00000011080	ENSCHIP00000003142	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.838
ACTB	FASN	ENSCHIP00000011080	ENSCHIP00000019407	Uncharacterized protein.	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	0.723
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	GOT1	ENSCHIP00000011080	ENSCHIP00000029101	Uncharacterized protein.	Aspartate aminotransferase.	0.779