(14 nodes) (2022) Inhibition of the Phospholipase Cepsilon-c-Jun N-Terminal Kinase Axis Suppresses Glioma Stem Cell Properties. network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	SOX2	HMG box domain-containing protein. (320 aa)
	NANOG	Homeobox domain-containing protein. (300 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
	ACTB	Uncharacterized protein. (375 aa)
	CCL5	C-C motif chemokine. (91 aa)
	BMI1	RING-type domain-containing protein. (437 aa)
	IL22	Interleukin 22. (190 aa)
	ALB	Serum albumin. (608 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	CCL2	C-C motif chemokine. (98 aa)
	GFAP	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (428 aa)
	NES	Nestin; Belongs to the intermediate filament family. (1606 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	BMI1	ENSCHIP00000011080	ENSCHIP00000016491	Uncharacterized protein.	RING-type domain-containing protein.	0.697
ACTB	CCL2	ENSCHIP00000011080	ENSCHIP00000027804	Uncharacterized protein.	C-C motif chemokine.	0.764
ACTB	CCL5	ENSCHIP00000011080	ENSCHIP00000016425	Uncharacterized protein.	C-C motif chemokine.	0.663
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	GFAP	ENSCHIP00000011080	ENSCHIP00000028106	Uncharacterized protein.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.868
ACTB	IL22	ENSCHIP00000011080	ENSCHIP00000019004	Uncharacterized protein.	Interleukin 22.	0.650
ACTB	IL6	ENSCHIP00000011080	ENSCHIP00000009414	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.919
ACTB	JUN	ENSCHIP00000011080	ENSCHIP00000001903	Uncharacterized protein.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.681
ACTB	NANOG	ENSCHIP00000011080	ENSCHIP00000009313	Uncharacterized protein.	Homeobox domain-containing protein.	0.781
ACTB	NES	ENSCHIP00000011080	ENSCHIP00000032395	Uncharacterized protein.	Nestin; Belongs to the intermediate filament family.	0.800
ACTB	SOX2	ENSCHIP00000011080	ENSCHIP00000007702	Uncharacterized protein.	HMG box domain-containing protein.	0.789
ACTB	TNF	ENSCHIP00000011080	ENSCHIP00000004561	Uncharacterized protein.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.886
ALB	ACTB	ENSCHIP00000020234	ENSCHIP00000011080	Serum albumin.	Uncharacterized protein.	0.961
ALB	BMI1	ENSCHIP00000020234	ENSCHIP00000016491	Serum albumin.	RING-type domain-containing protein.	0.495
ALB	CCL2	ENSCHIP00000020234	ENSCHIP00000027804	Serum albumin.	C-C motif chemokine.	0.748
ALB	CCL5	ENSCHIP00000020234	ENSCHIP00000016425	Serum albumin.	C-C motif chemokine.	0.686
ALB	GAPDH	ENSCHIP00000020234	ENSCHIP00000025974	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.948
ALB	GFAP	ENSCHIP00000020234	ENSCHIP00000028106	Serum albumin.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.884
ALB	IL22	ENSCHIP00000020234	ENSCHIP00000019004	Serum albumin.	Interleukin 22.	0.552