(36 nodes) (2022) Long-term culture of patient-derived cardiac organoids recapitulated Duchenne muscular dystrophy cardiomyopathy and disease progression. network (Capra hircus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ARCN1	Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (510 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
	PGK1	Phosphoglycerate kinase. (424 aa)
	ACTN2	Actinin alpha 2. (902 aa)
	GDF10	Bone morphogenetic protein 3; Belongs to the TGF-beta family. (478 aa)
	TNNC2	Uncharacterized protein. (160 aa)
	HCN4	Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1203 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	ACADL	Acyl-CoA dehydrogenase long chain. (430 aa)
	SIRPA	Uncharacterized protein. (506 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	GORASP2	Golgi reassembly stacking protein 2. (455 aa)
	SGCA	Sarcoglycan alpha. (388 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	ACTN1	Actinin alpha 1. (914 aa)
	OGN	Uncharacterized protein. (299 aa)
	TNNI1	Troponin I1, slow skeletal type. (187 aa)
	MYH6	Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1943 aa)
	MGP	Matrix Gla protein; Associates with the organic matrix of bone and cartilage. (101 aa)
	ALB	Serum albumin. (608 aa)
	ACSL5	Acyl-CoA synthetase long chain family member 5. (683 aa)
	MYL2	Myosin light chain 2. (178 aa)
	TPM1	Uncharacterized protein; Belongs to the tropomyosin family. (284 aa)
	TNNT2	Troponin T2, cardiac type. (267 aa)
	MYH7	Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1955 aa)
	NOX4	NADPH oxidase 4. (578 aa)
	MYL7	Myosin light chain 7. (175 aa)
	MYBPC3	Myosin binding protein C, cardiac. (1303 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	NOTCH2	Notch receptor 2. (2471 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
	HAPLN1	Hyaluronan and proteoglycan link protein 1. (354 aa)
	IRX4	Iroquois homeobox 4. (604 aa)
	CCND2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
	COL1A2	Collagen type I alpha 2 chain. (1128 aa)
	APP	Amyloid beta precursor protein. (770 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACADL	ACSL5	ENSCHIP00000009763	ENSCHIP00000021425	Acyl-CoA dehydrogenase long chain.	Acyl-CoA synthetase long chain family member 5.	0.641
ACADL	PPARG	ENSCHIP00000009763	ENSCHIP00000015163	Acyl-CoA dehydrogenase long chain.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.576
ACSL5	ACADL	ENSCHIP00000021425	ENSCHIP00000009763	Acyl-CoA synthetase long chain family member 5.	Acyl-CoA dehydrogenase long chain.	0.641
ACSL5	PPARG	ENSCHIP00000021425	ENSCHIP00000015163	Acyl-CoA synthetase long chain family member 5.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.430
ACTN1	GAPDH	ENSCHIP00000015198	ENSCHIP00000025974	Actinin alpha 1.	Glyceraldehyde-3-phosphate dehydrogenase.	0.510
ACTN1	MYBPC3	ENSCHIP00000015198	ENSCHIP00000025176	Actinin alpha 1.	Myosin binding protein C, cardiac.	0.491
ACTN1	MYH6	ENSCHIP00000015198	ENSCHIP00000017471	Actinin alpha 1.	Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.535
ACTN1	MYH7	ENSCHIP00000015198	ENSCHIP00000024142	Actinin alpha 1.	Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.546
ACTN1	MYL2	ENSCHIP00000015198	ENSCHIP00000021875	Actinin alpha 1.	Myosin light chain 2.	0.431
ACTN1	TNNC2	ENSCHIP00000015198	ENSCHIP00000006884	Actinin alpha 1.	Uncharacterized protein.	0.551
ACTN1	TNNI1	ENSCHIP00000015198	ENSCHIP00000016174	Actinin alpha 1.	Troponin I1, slow skeletal type.	0.577
ACTN1	TNNT2	ENSCHIP00000015198	ENSCHIP00000022908	Actinin alpha 1.	Troponin T2, cardiac type.	0.546
ACTN1	TPM1	ENSCHIP00000015198	ENSCHIP00000022213	Actinin alpha 1.	Uncharacterized protein; Belongs to the tropomyosin family.	0.597
ACTN2	GAPDH	ENSCHIP00000006208	ENSCHIP00000025974	Actinin alpha 2.	Glyceraldehyde-3-phosphate dehydrogenase.	0.448
ACTN2	HCN4	ENSCHIP00000006208	ENSCHIP00000008186	Actinin alpha 2.	Hyperpolarization activated cyclic nucleotide gated potassium channel 4.	0.503
ACTN2	MYBPC3	ENSCHIP00000006208	ENSCHIP00000025176	Actinin alpha 2.	Myosin binding protein C, cardiac.	0.803
ACTN2	MYH6	ENSCHIP00000006208	ENSCHIP00000017471	Actinin alpha 2.	Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.870
ACTN2	MYH7	ENSCHIP00000006208	ENSCHIP00000024142	Actinin alpha 2.	Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.910
ACTN2	MYL2	ENSCHIP00000006208	ENSCHIP00000021875	Actinin alpha 2.	Myosin light chain 2.	0.822
ACTN2	MYL7	ENSCHIP00000006208	ENSCHIP00000025115	Actinin alpha 2.	Myosin light chain 7.	0.775