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PSMD3 PSMD3 JUN JUN RBBP4-2 RBBP4-2 POLE POLE PSMD11 PSMD11 RRM2 RRM2 CD4 CD4 RAB11A RAB11A PSMA2 PSMA2 HDAC7 HDAC7 ST3GAL4 ST3GAL4 IL7 IL7 ACTB ACTB ZNF10 ZNF10 CXCR3 CXCR3 RBBP4 RBBP4 SAP30 SAP30 POLA1 POLA1 HDAC5 HDAC5 VCP VCP PSMD7 PSMD7 HDAC4 HDAC4 DNA2 DNA2 PPIB PPIB HDAC1 HDAC1 SIN3A SIN3A RBBP7 RBBP7 GAPDH GAPDH SEL1L SEL1L MECP2 MECP2 RPA3 RPA3 HDAC2 HDAC2 SP3 SP3 IL15 IL15 IL2 IL2 TP53 TP53 HDAC9 HDAC9 PSMD8 PSMD8 TOPBP1 TOPBP1 BRCA1 BRCA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMD3Proteasome 26S subunit, non-ATPase 3. (537 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
RBBP4-2WD_REPEATS_REGION domain-containing protein. (425 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2281 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (389 aa)
CD4CD4 molecule. (455 aa)
RAB11ARAB11A, member RAS oncogene family. (216 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1062 aa)
ST3GAL4ST3 beta-galactoside alpha-2,3-sialyltransferase 4; Belongs to the glycosyltransferase 29 family. (336 aa)
IL7Interleukin 7. (181 aa)
ACTBUncharacterized protein. (375 aa)
ZNF10Uncharacterized protein. (571 aa)
CXCR3C-X-C chemokine receptor type 3; Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity). (367 aa)
RBBP4WD_REPEATS_REGION domain-containing protein. (426 aa)
SAP30Sin3A associated protein 30. (220 aa)
POLA1DNA polymerase. (1468 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1142 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (816 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
DNA2DNA replication helicase/nuclease 2. (1062 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (464 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (469 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
SEL1LSEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (794 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (481 aa)
RPA3Uncharacterized protein. (121 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
SP3Sp3 transcription factor. (778 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (161 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1069 aa)
PSMD8Proteasome 26S subunit, non-ATPase 8. (287 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1521 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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