41 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CYP20A1	Cytochrome P450 family 20 subfamily A member 1. (462 aa)
	PSAT1	Phosphoserine aminotransferase. (370 aa)
	CALR	Calreticulin. (417 aa)
	XBP1	BZIP domain-containing protein. (261 aa)
	ABCB10	ATP binding cassette subfamily B member 10. (433 aa)
	ABCG5	ATP binding cassette subfamily G member 5. (649 aa)
	HSPA5	Heat shock 70kDa protein 5; Belongs to the heat shock protein 70 family. (655 aa)
	ALDH1L2	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (923 aa)
	HSPA9	Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa)
	SFXN5	Sidoreflexin. (331 aa)
	TIMM9	Translocase of inner mitochondrial membrane 9. (89 aa)
	MTHFD2	Uncharacterized protein. (352 aa)
	FOXJ3	Forkhead box J3. (628 aa)
	PUM2	Pumilio RNA binding family member 2. (1064 aa)
	CYB5R2	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (305 aa)
	SLC25A35	Solute carrier family 25 member 35; Belongs to the mitochondrial carrier (TC 2.A.29) family. (249 aa)
	MTHFD1L	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (975 aa)
	SLC30A2	Solute carrier family 30 member 2. (347 aa)
	SFXN1	Sidoreflexin. (322 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	ATP6	ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (226 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (502 aa)
	COMTD1	Catechol-O-methyltransferase domain containing 1. (262 aa)
	SFXN3	Sidoreflexin. (321 aa)
	TOMM20	Translocase of outer mitochondrial membrane 20. (145 aa)
	MYOD1	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
	SEC61A1	SEC61 translocon alpha 1 subunit. (476 aa)
	EEF1A1	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
	LOC108637636	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
	ABCB4	ATP binding cassette subfamily B member 4. (1267 aa)
	SFXN4	Sideroflexin 4. (313 aa)
	SLC39A10	Solute carrier family 39 member 10. (833 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
	LOC102182663	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (509 aa)
	MPC1	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (96 aa)
	PXDN	Peroxidasin. (1525 aa)
	RCN2	Reticulocalbin 2. (317 aa)
	SLC16A1	MFS domain-containing protein. (501 aa)
	LDH-A	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
	PHGDH	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
	ATF6	Activating transcription factor 6. (664 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB10	ABCG5	ENSCHIP00000028751	ENSCHIP00000029032	ATP binding cassette subfamily B member 10.	ATP binding cassette subfamily G member 5.	0.406
ABCB4	ABCG5	ENSCHIP00000008304	ENSCHIP00000029032	ATP binding cassette subfamily B member 4.	ATP binding cassette subfamily G member 5.	0.517
ABCG5	ABCB10	ENSCHIP00000029032	ENSCHIP00000028751	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily B member 10.	0.406
ABCG5	ABCB4	ENSCHIP00000029032	ENSCHIP00000008304	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily B member 4.	0.517
ABCG5	HMGCS1	ENSCHIP00000029032	ENSCHIP00000013847	ATP binding cassette subfamily G member 5.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.666
ALDH1L2	MTHFD1L	ENSCHIP00000021223	ENSCHIP00000032334	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	0.667
ALDH1L2	MTHFD2	ENSCHIP00000021223	ENSCHIP00000024076	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	Uncharacterized protein.	0.977
ALDH1L2	PHGDH	ENSCHIP00000021223	ENSCHIP00000019405	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.621
ALDH1L2	PSAT1	ENSCHIP00000021223	ENSCHIP00000027621	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	Phosphoserine aminotransferase.	0.633
ALDH1L2	SHMT2	ENSCHIP00000021223	ENSCHIP00000001693	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.970
ATF6	CALR	ENSCHIP00000019493	ENSCHIP00000027670	Activating transcription factor 6.	Calreticulin.	0.858
ATF6	GAPDH	ENSCHIP00000019493	ENSCHIP00000025974	Activating transcription factor 6.	Glyceraldehyde-3-phosphate dehydrogenase.	0.780
ATF6	HSPA5	ENSCHIP00000019493	ENSCHIP00000030268	Activating transcription factor 6.	Heat shock 70kDa protein 5; Belongs to the heat shock protein 70 family.	0.999
ATF6	PXDN	ENSCHIP00000019493	ENSCHIP00000015493	Activating transcription factor 6.	Peroxidasin.	0.700
ATF6	XBP1	ENSCHIP00000019493	ENSCHIP00000027960	Activating transcription factor 6.	BZIP domain-containing protein.	0.981
ATP6	GAPDH	ENSCHIP00000000006	ENSCHIP00000025974	ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...]	Glyceraldehyde-3-phosphate dehydrogenase.	0.463
ATP6	SEC61A1	ENSCHIP00000000006	ENSCHIP00000006176	ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...]	SEC61 translocon alpha 1 subunit.	0.584
CALR	ATF6	ENSCHIP00000027670	ENSCHIP00000019493	Calreticulin.	Activating transcription factor 6.	0.858
CALR	GAPDH	ENSCHIP00000027670	ENSCHIP00000025974	Calreticulin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.736
CALR	HSPA5	ENSCHIP00000027670	ENSCHIP00000030268	Calreticulin.	Heat shock 70kDa protein 5; Belongs to the heat shock protein 70 family.	0.978