STRINGSTRING
RAD51AP1 RAD51AP1 UBE2A UBE2A BMPR1A BMPR1A LIG4 LIG4 FANCI FANCI SDHD SDHD BABAM2 BABAM2 FANCA FANCA HRAS HRAS PTEN PTEN RAD50 RAD50 APEX1 APEX1 FANCF FANCF EZH2 EZH2 POLE POLE RNF8 RNF8 LOC108634548 LOC108634548 TERT TERT FSBP FSBP RAD18 RAD18 ALK ALK SHPRH SHPRH RAD52 RAD52 SDHC SDHC RFC2 RFC2 EXT1 EXT1 RECQL5 RECQL5 ERCC6 ERCC6 PALB2 PALB2 TP53BP1 TP53BP1 AXIN1 AXIN1 MDM4 MDM4 XPA XPA CCND1 CCND1 PIK3CG PIK3CG EYA2 EYA2 NF1 NF1 INS INS SOX2 SOX2 RECQL4 RECQL4 MUTYH MUTYH OTX2 OTX2 PRKAR1A PRKAR1A CEBPA CEBPA ESR2 ESR2 CSNK1D CSNK1D TMEM127 TMEM127 NANOG NANOG SMARCE1 SMARCE1 DNAJC21 DNAJC21 CDKN1C CDKN1C XRCC6 XRCC6 TELO2 TELO2 KCNJ5 KCNJ5 EXO1 EXO1 NCAM1 NCAM1 WT1 WT1 RBBP8 RBBP8 CWF19L2 CWF19L2 SDHB SDHB CEP57 CEP57 UBE2V2 UBE2V2 FOXA2 FOXA2 PTCH1 PTCH1 PRKDC PRKDC ESR1 ESR1 NF2 NF2 MSH6 MSH6 ERCC5 ERCC5 TSC2 TSC2 SETBP1 SETBP1 RAD9A RAD9A VTN VTN RAD51B RAD51B ERCC3 ERCC3 GATA2 GATA2 MDC1 MDC1 NHEJ1 NHEJ1 WRN WRN FANCM FANCM RAD51C RAD51C SMARCA4 SMARCA4 KAT5 KAT5 DCLRE1C DCLRE1C FANCB FANCB MGMT MGMT PCNA PCNA DICER1 DICER1 CDKN1B CDKN1B BUB1B BUB1B DHFR DHFR DPYD DPYD PREX2 PREX2 ABRAXAS1 ABRAXAS1 ATM ATM RUNX1 RUNX1 PMS2 PMS2 SLX4 SLX4 PHOX2B PHOX2B UBE2I UBE2I SDHA SDHA EPHX1 EPHX1 GPC3 GPC3 TLR4 TLR4 TSHR TSHR POLD1 POLD1 ALB ALB FANCL FANCL CASP8 CASP8 SMAD4 SMAD4 RAD51D RAD51D SMARCB1 SMARCB1 MDM2 MDM2 RAD54L RAD54L HELQ HELQ CDK4 CDK4 EGFR EGFR SETX SETX XRCC1 XRCC1 LMO1 LMO1 RAD17 RAD17 RFC4 RFC4 XRCC3 XRCC3 BRCA2 BRCA2 RET RET DDB2 DDB2 MRE11 MRE11 BARD1 BARD1 ABRAXAS2 ABRAXAS2 FANCG FANCG STK11 STK11 FANCC FANCC SUFU SUFU XRCC5 XRCC5 DIS3L2 DIS3L2 CDC73 CDC73 PLA2G2A PLA2G2A ATMIN ATMIN KIT KIT ERCC4 ERCC4 RAD23B RAD23B RNF146 RNF146 OGG1 OGG1 UIMC1 UIMC1 EPCAM EPCAM ERCC2 ERCC2 UBE4B UBE4B RNF168 RNF168 CLSPN CLSPN SDHAF2 SDHAF2 CHEK2 CHEK2 PPM1D PPM1D MUS81 MUS81 FANCE FANCE HUS1 HUS1 ATRIP ATRIP RECQL RECQL FBXW7 FBXW7 AURKA AURKA TERF2 TERF2 RHBDF2 RHBDF2 NSD1 NSD1 BABAM1 BABAM1 TP53 TP53 CHEK1 CHEK1 GADD45A GADD45A ERCC1 ERCC1 TLR2 TLR2 CDKN2A CDKN2A EXT2 EXT2 CYLD CYLD NFKBIZ NFKBIZ FANCD2 FANCD2 MSH3 MSH3 TOPBP1 TOPBP1 HOXB13 HOXB13 BRCA1 BRCA1 SBDS SBDS MMP8 MMP8 NELFB NELFB GRB7 GRB7 FLCN FLCN
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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RAD51AP1RAD51 associated protein 1. (326 aa)
UBE2AUbiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LIG4DNA ligase. (911 aa)
FANCIFA complementation group I. (1086 aa)
SDHDSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
BABAM2BRISC and BRCA1 A complex member 2. (383 aa)
FANCAFA complementation group A. (1416 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
RAD50Zinc-hook domain-containing protein. (1332 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
FANCFFA complementation group F. (359 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2281 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (504 aa)
LOC108634548Uncharacterized protein. (190 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1123 aa)
FSBPUncharacterized protein. (909 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (502 aa)
ALKTyrosine-protein kinase receptor. (1309 aa)
SHPRHSNF2 histone linker PHD RING helicase. (1685 aa)
RAD52RAD52 homolog, DNA repair protein. (416 aa)
SDHCSuccinate dehydrogenase complex subunit C. (169 aa)
RFC2Replication factor C subunit 2. (352 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (446 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1481 aa)
PALB2Partner and localizer of BRCA2. (1194 aa)
TP53BP1Tumor protein p53 binding protein 1. (1966 aa)
AXIN1Axin 1. (867 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (491 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (552 aa)
NF1Neurofibromin 1. (2848 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
SOX2HMG box domain-containing protein. (320 aa)
RECQL4RecQ like helicase 4. (1176 aa)
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (605 aa)
OTX2Homeobox domain-containing protein. (289 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (380 aa)
CEBPACCAAT enhancer binding protein alpha. (353 aa)
ESR2Uncharacterized protein. (527 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (415 aa)
TMEM127Transmembrane protein 127. (238 aa)
NANOGHomeobox domain-containing protein. (300 aa)
SMARCE1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa)
DNAJC21DnaJ heat shock protein family (Hsp40) member C21. (533 aa)
CDKN1CCyclin dependent kinase inhibitor 1C. (254 aa)
XRCC6X-ray repair cross complementing 6. (607 aa)
TELO2Telomere maintenance 2. (825 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
EXO1Exonuclease 1. (835 aa)
NCAM1Neural cell adhesion molecule 1. (1007 aa)
WT1WT1 transcription factor. (450 aa)
RBBP8RB binding protein 8, endonuclease. (889 aa)
CWF19L2CWF19 like cell cycle control factor 2. (884 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (280 aa)
CEP57Centrosomal protein 57. (502 aa)
UBE2V2Ubiquitin conjugating enzyme E2 V2. (148 aa)
FOXA2Forkhead box A2. (467 aa)
PTCH1Patched 1. (1453 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4117 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
NF2FERM domain-containing protein. (612 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
ERCC5ERCC excision repair 5, endonuclease. (1190 aa)
TSC2Rap-GAP domain-containing protein. (1817 aa)
SETBP1SET binding protein 1. (1595 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (395 aa)
VTNSMB domain-containing protein. (475 aa)
RAD51BRAD51 paralog B. (270 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
GATA2GATA binding protein 2. (480 aa)
MDC1Mediator of DNA damage checkpoint 1. (1914 aa)
NHEJ1Non-homologous end joining factor 1. (299 aa)
WRNWRN RecQ like helicase. (1405 aa)
FANCMFA complementation group M. (2043 aa)
RAD51CRAD51 paralog C. (371 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1606 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
DCLRE1CDNA cross-link repair 1C. (710 aa)
FANCBUncharacterized protein. (447 aa)
MGMTO-6-methylguanine-DNA methyltransferase. (222 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1922 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
BUB1BUncharacterized protein. (1062 aa)
DHFRDHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa)
DPYDDihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1033 aa)
PREX2Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1605 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (410 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (453 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (887 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1752 aa)
PHOX2BPaired like homeobox 2B. (315 aa)
UBE2IUbiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
SDHASuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (665 aa)
EPHX1Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. (461 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (509 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (817 aa)
POLD1DNA polymerase. (1115 aa)
ALBSerum albumin. (608 aa)
FANCLRING-type domain-containing protein. (379 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (488 aa)
SMAD4Mothers against decapentaplegic homolog. (513 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (338 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (395 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
RAD54LRAD54 like. (749 aa)
HELQHelicase, POLQ like. (1115 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
SETXSenataxin. (2659 aa)
XRCC1X-ray repair cross complementing 1. (632 aa)
LMO1LIM domain only 1. (155 aa)
RAD17RAD17 checkpoint clamp loader component. (709 aa)
RFC4Replication factor C subunit 4. (364 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (341 aa)
BRCA2BRCA2 DNA repair associated. (3405 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1118 aa)
DDB2Damage specific DNA binding protein 2. (411 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (724 aa)
BARD1BRCA1 associated RING domain 1. (775 aa)
ABRAXAS2MPN domain-containing protein. (404 aa)
FANCGFA complementation group G. (616 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (568 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
XRCC5X-ray repair cross complementing 5. (736 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (882 aa)
CDC73Cell division cycle 73. (531 aa)
PLA2G2APhospholipase A(2). (144 aa)
ATMINATM interactor. (821 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (974 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (408 aa)
RNF146Uncharacterized protein. (352 aa)
OGG18-oxoguanine DNA glycosylase. (345 aa)
UIMC1Ubiquitin interaction motif containing 1. (795 aa)
EPCAMEpithelial cell adhesion molecule. (314 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
UBE4BUbiquitination factor E4B. (1153 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa)
CLSPNClaspin. (1339 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (166 aa)
CHEK2Checkpoint kinase 2. (534 aa)
PPM1DProtein phosphatase, Mg2+/Mn2+ dependent 1D. (605 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
FANCEFA complementation group E. (444 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
ATRIPATR interacting protein. (791 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa)
FBXW7F-box and WD repeat domain containing 7. (705 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (405 aa)
TERF2Telomeric repeat binding factor 2. (543 aa)
RHBDF2Rhomboid 5 homolog 2. (830 aa)
NSD1Nuclear receptor binding SET domain protein 1. (2698 aa)
BABAM1BRISC and BRCA1 A complex member 1. (332 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (294 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (794 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (157 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (737 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (953 aa)
NFKBIZMolecule possessing ankyrin-repeats induced by lipopolysaccharide. (719 aa)
FANCD2FA complementation group D2. (1423 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1119 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1521 aa)
HOXB13Homeobox B13. (285 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
SBDSSBDS ribosome maturation factor. (250 aa)
MMP8Matrix metallopeptidase 8. (470 aa)
NELFBNegative elongation factor complex member B. (817 aa)
GRB7Growth factor receptor bound protein 7. (532 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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