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RNASEH2B RNASEH2B USP15 USP15 RAD52 RAD52 FEN1 FEN1 TIGAR TIGAR GPBP1 GPBP1 MLH3 MLH3 PALB2 PALB2 CCND1 CCND1 EHMT1 EHMT1 ARID1A ARID1A NF1 NF1 HMGB2 HMGB2 NBN NBN XAB2 XAB2 SSRP1 SSRP1 MLH1 MLH1 TWIST1 TWIST1 BCL2L2 BCL2L2 REV1 REV1 XRCC6 XRCC6 GABPA GABPA RBBP8 RBBP8 EHMT2 EHMT2 TRIP12 TRIP12 CASP3 CASP3 MYC MYC ATRX ATRX POLQ POLQ HMGA2 HMGA2 RNASEH2A RNASEH2A RAD51B RAD51B ERCC3 ERCC3 DNPH1 DNPH1 SHLD1 SHLD1 DDB1 DDB1 RAD51C RAD51C CDK12 CDK12 DCLRE1C DCLRE1C PARG PARG BRD9 BRD9 PCNA PCNA PARP3 PARP3 PIK3CA PIK3CA MAPK12 MAPK12 ATM ATM ERCC8 ERCC8 PARP1 PARP1 BRD4 BRD4 ALB ALB DYNLL1 DYNLL1 RAD51D RAD51D INPP4B INPP4B STK36 STK36 USP13 USP13 SEM1 SEM1 CDK4 CDK4 XRCC1 XRCC1 ENDOG ENDOG XRCC3 XRCC3 BRCA2 BRCA2 TSSK3 TSSK3 BARD1 BARD1 XRCC5 XRCC5 HSP90AA1 HSP90AA1 AURKB AURKB RNF168 RNF168 E2F7 E2F7 RPA3 RPA3 RPRD1B RPRD1B CHEK2 CHEK2 PNKP PNKP MUS81 MUS81 BCL2L1 BCL2L1 PARP2 PARP2 CCNE1 CCNE1 CDK9 CDK9 CBLC CBLC TP53 TP53 CHEK1 CHEK1 FOXM1 FOXM1 CDK5 CDK5 RPA1 RPA1 LIG1 LIG1 TOPBP1 TOPBP1 FBXO5 FBXO5 BRCA1 BRCA1 CDCA8 CDCA8 RAD51 RAD51 SHLD2 SHLD2 PLK3 PLK3 SRC SRC PTEN PTEN PDS5B PDS5B RAD50 RAD50 EZH2 EZH2 NRP1 NRP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RNASEH2BUncharacterized protein. (306 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
RAD52RAD52 homolog, DNA repair protein. (416 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (270 aa)
GPBP1GC-rich promoter binding protein 1. (493 aa)
MLH3MutL homolog 3. (1463 aa)
PALB2Partner and localizer of BRCA2. (1194 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
EHMT1Euchromatic histone lysine methyltransferase 1. (1293 aa)
ARID1AAT-rich interaction domain 1A. (2285 aa)
NF1Neurofibromin 1. (2848 aa)
HMGB2Uncharacterized protein. (209 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (754 aa)
XAB2XPA binding protein 2. (892 aa)
SSRP1FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (709 aa)
MLH1MutL homolog 1. (758 aa)
TWIST1BHLH domain-containing protein. (163 aa)
BCL2L2BCL2 like 2. (193 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1254 aa)
XRCC6X-ray repair cross complementing 6. (607 aa)
GABPAGA binding protein transcription factor subunit alpha. (454 aa)
RBBP8RB binding protein 8, endonuclease. (889 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1268 aa)
TRIP12Thyroid hormone receptor interactor 12. (2067 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (275 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
ATRXATRX chromatin remodeler. (2105 aa)
POLQDNA polymerase theta. (2587 aa)
HMGA2Uncharacterized protein. (104 aa)
RNASEH2ARibonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (301 aa)
RAD51BRAD51 paralog B. (270 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
DNPH12'-deoxynucleoside 5'-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. (198 aa)
SHLD1Shieldin complex subunit 1. (206 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
RAD51CRAD51 paralog C. (371 aa)
CDK12Cyclin dependent kinase 12. (1490 aa)
DCLRE1CDNA cross-link repair 1C. (710 aa)
PARGPoly(ADP-ribose) glycohydrolase. (972 aa)
BRD9Bromodomain containing 9. (577 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
PARP3Poly [ADP-ribose] polymerase. (525 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MAPK12Mitogen-activated protein kinase 12. (359 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (397 aa)
PARP1Poly [ADP-ribose] polymerase. (1020 aa)
BRD4Uncharacterized protein. (1336 aa)
ALBSerum albumin. (608 aa)
DYNLL1Dynein light chain. (89 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (338 aa)
INPP4BInositol polyphosphate-4-phosphatase type II B. (939 aa)
STK36Serine/threonine kinase 36. (1310 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (863 aa)
SEM1Uncharacterized protein. (63 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
XRCC1X-ray repair cross complementing 1. (632 aa)
ENDOGEndonuclease. (299 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (341 aa)
BRCA2BRCA2 DNA repair associated. (3405 aa)
TSSK3Testis specific serine kinase 3. (269 aa)
BARD1BRCA1 associated RING domain 1. (775 aa)
XRCC5X-ray repair cross complementing 5. (736 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (733 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa)
E2F7E2F transcription factor 7. (911 aa)
RPA3Uncharacterized protein. (121 aa)
RPRD1BRPR domain containing protein. (326 aa)
CHEK2Checkpoint kinase 2. (534 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (522 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
BCL2L1BH4_2 domain-containing protein. (233 aa)
PARP2Poly [ADP-ribose] polymerase. (533 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (411 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
CBLCCbl proto-oncogene C. (489 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
FOXM1Fork-head domain-containing protein. (763 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
LIG1DNA ligase. (915 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1521 aa)
FBXO5F-box protein 5. (448 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
CDCA8Cell division cycle associated 8. (280 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
SHLD2Shieldin complex subunit 2. (918 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
SRCTyrosine-protein kinase. (538 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
PDS5BPDS5 cohesin associated factor B. (1448 aa)
RAD50Zinc-hook domain-containing protein. (1332 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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