19 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	NQO1	NAD(P)H quinone dehydrogenase 1. (274 aa)
	TYRP1	Uncharacterized protein. (537 aa)
	CD38	Uncharacterized protein. (277 aa)
	DHODH	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (395 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	LCN2	Lipocalin 2; Belongs to the calycin superfamily. Lipocalin family. (200 aa)
	FTH1	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (181 aa)
	HMGB1	Uncharacterized protein. (215 aa)
	DHFR	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (571 aa)
	GOT2	Aspartate aminotransferase. (430 aa)
	CALR	Calreticulin. (417 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	CD34	Uncharacterized protein. (384 aa)
	TYR	Tyrosinase. (530 aa)
	GPX4	Uncharacterized protein. (190 aa)
	GOT1	Aspartate aminotransferase. (413 aa)
	FTL	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (175 aa)
	GCLM	Glutamate-cysteine ligase modifier subunit. (274 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALR	GAPDH	ENSCHIP00000027670	ENSCHIP00000025974	Calreticulin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.736
CALR	HMGB1	ENSCHIP00000027670	ENSCHIP00000019478	Calreticulin.	Uncharacterized protein.	0.799
CALR	TNF	ENSCHIP00000027670	ENSCHIP00000004561	Calreticulin.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.444
CD34	CD38	ENSCHIP00000002645	ENSCHIP00000001838	Uncharacterized protein.	Uncharacterized protein.	0.895
CD34	GAPDH	ENSCHIP00000002645	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.843
CD34	GOT1	ENSCHIP00000002645	ENSCHIP00000029101	Uncharacterized protein.	Aspartate aminotransferase.	0.403
CD34	GOT2	ENSCHIP00000002645	ENSCHIP00000010968	Uncharacterized protein.	Aspartate aminotransferase.	0.464
CD34	TNF	ENSCHIP00000002645	ENSCHIP00000004561	Uncharacterized protein.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.698
CD38	CD34	ENSCHIP00000001838	ENSCHIP00000002645	Uncharacterized protein.	Uncharacterized protein.	0.895
CD38	GAPDH	ENSCHIP00000001838	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.570
CD38	TNF	ENSCHIP00000001838	ENSCHIP00000004561	Uncharacterized protein.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.672
DHFR	DHODH	ENSCHIP00000015609	ENSCHIP00000000709	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	0.618
DHFR	GAPDH	ENSCHIP00000015609	ENSCHIP00000025974	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.497
DHODH	DHFR	ENSCHIP00000000709	ENSCHIP00000015609	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	0.618
FTH1	FTL	ENSCHIP00000020262	ENSCHIP00000030044	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	0.996
FTH1	GAPDH	ENSCHIP00000020262	ENSCHIP00000025974	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	Glyceraldehyde-3-phosphate dehydrogenase.	0.592
FTH1	GCLM	ENSCHIP00000020262	ENSCHIP00000030553	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	Glutamate-cysteine ligase modifier subunit.	0.441
FTH1	GPX4	ENSCHIP00000020262	ENSCHIP00000028055	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	Uncharacterized protein.	0.847
FTH1	NQO1	ENSCHIP00000020262	ENSCHIP00000031320	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	NAD(P)H quinone dehydrogenase 1.	0.498
FTL	FTH1	ENSCHIP00000030044	ENSCHIP00000020262	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	0.996