(35 nodes) (2022) 13-Acetoxysarcocrassolide induces apoptosis in human hepatocellular carcinoma cells through mitochondrial dysfunction and suppression of the PI3KAKTmTORp70S6K signalling pathway. network (Capra hircus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	LOC102176495	Annexin. (331 aa)
	ANXA11	Annexin. (503 aa)
	ANXA7	Annexin. (485 aa)
	ANXA2	Annexin. (339 aa)
	EIF4E	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
	ANXA3	Annexin. (323 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (452 aa)
	KEAP1	Kelch like ECH associated protein 1. (624 aa)
	ANXA13	Annexin. (371 aa)
	EIF4B	RRM domain-containing protein. (615 aa)
	ENSCHIP00000009938	Annexin. (100 aa)
	ACTB	Uncharacterized protein. (375 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1095 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	PXDN	Peroxidasin. (1525 aa)
	MMP2	Matrix metallopeptidase 2. (661 aa)
	BCL2	BH4_2 domain-containing protein. (229 aa)
	BAX	BCL2 associated X, apoptosis regulator. (192 aa)
	ANXA6	Annexin. (689 aa)
	MMP9	Uncharacterized protein. (709 aa)
	PARP1	Poly [ADP-ribose] polymerase. (1020 aa)
	EIF4EBP1	Uncharacterized protein. (118 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	ENSCHIP00000022284	Annexin. (275 aa)
	ENDOG	Endonuclease. (299 aa)
	ANXA1	Annexin. (346 aa)
	ANXA5	Annexin. (334 aa)
	LOC108634039	Annexin. (449 aa)
	ANXA9	Annexin. (345 aa)
	LOC102173997	Capra hircus breed Kapro cytochrome c mRNA; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
	LOC106501717	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	MCL1	MCL1 apoptosis regulator, BCL2 family member. (350 aa)
	ANXA4	Annexin. (320 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ANXA1	ENSCHIP00000011080	ENSCHIP00000023293	Uncharacterized protein.	Annexin.	0.799
ACTB	ANXA11	ENSCHIP00000011080	ENSCHIP00000000173	Uncharacterized protein.	Annexin.	0.767
ACTB	ANXA13	ENSCHIP00000011080	ENSCHIP00000009473	Uncharacterized protein.	Annexin.	0.768
ACTB	ANXA2	ENSCHIP00000011080	ENSCHIP00000002620	Uncharacterized protein.	Annexin.	0.870
ACTB	ANXA3	ENSCHIP00000011080	ENSCHIP00000008438	Uncharacterized protein.	Annexin.	0.768
ACTB	ANXA4	ENSCHIP00000011080	ENSCHIP00000033451	Uncharacterized protein.	Annexin.	0.769
ACTB	ANXA5	ENSCHIP00000011080	ENSCHIP00000024678	Uncharacterized protein.	Annexin.	0.867
ACTB	ANXA6	ENSCHIP00000011080	ENSCHIP00000016041	Uncharacterized protein.	Annexin.	0.768
ACTB	ANXA7	ENSCHIP00000011080	ENSCHIP00000000188	Uncharacterized protein.	Annexin.	0.767
ACTB	ANXA9	ENSCHIP00000011080	ENSCHIP00000028656	Uncharacterized protein.	Annexin.	0.768
ACTB	APAF1	ENSCHIP00000011080	ENSCHIP00000031955	Uncharacterized protein.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.729
ACTB	BCL2	ENSCHIP00000011080	ENSCHIP00000015831	Uncharacterized protein.	BH4_2 domain-containing protein.	0.940
ACTB	CASP3	ENSCHIP00000011080	ENSCHIP00000011490	Uncharacterized protein.	Caspase 3; Belongs to the peptidase C14A family.	0.996
ACTB	CASP9	ENSCHIP00000011080	ENSCHIP00000008590	Uncharacterized protein.	Caspase 9; Belongs to the peptidase C14A family.	0.891
ACTB	EIF4B	ENSCHIP00000011080	ENSCHIP00000009582	Uncharacterized protein.	RRM domain-containing protein.	0.429
ACTB	EIF4E	ENSCHIP00000011080	ENSCHIP00000005408	Uncharacterized protein.	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family.	0.712
ACTB	EIF4EBP1	ENSCHIP00000011080	ENSCHIP00000020433	Uncharacterized protein.	Uncharacterized protein.	0.589
ACTB	ENDOG	ENSCHIP00000011080	ENSCHIP00000023037	Uncharacterized protein.	Endonuclease.	0.456
ACTB	ENSCHIP00000009938	ENSCHIP00000011080	ENSCHIP00000009938	Uncharacterized protein.	Annexin.	0.767
ACTB	ENSCHIP00000022284	ENSCHIP00000011080	ENSCHIP00000022284	Uncharacterized protein.	Annexin.	0.806