STRINGSTRING
CD44 CD44 AR AR HNRNPAB HNRNPAB RRM2B RRM2B GAPDH GAPDH TMPRSS2 TMPRSS2 TP53 TP53 TP53BP2 TP53BP2 FOXM1 FOXM1 HOXB13 HOXB13 HOXC8 HOXC8 NANOG NANOG ESR1 ESR1 TP53INP1 TP53INP1 STAT3 STAT3 LEP LEP HOXB7 HOXB7 KLF4 KLF4 DLL4 DLL4 DLL1 DLL1 JAG1 JAG1 CD63 CD63
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD44CD44 molecule (Indian blood group). (715 aa)
ARAndrogen receptor. (891 aa)
HNRNPABHeterogeneous nuclear ribonucleoprotein A/B. (332 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (351 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (492 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
TP53BP2Tumor protein p53 binding protein 2. (1135 aa)
FOXM1Fork-head domain-containing protein. (763 aa)
HOXB13Homeobox B13. (285 aa)
HOXC8Homeobox C8. (242 aa)
NANOGHomeobox domain-containing protein. (300 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (596 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (240 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)
HOXB7Homeobox B7. (217 aa)
KLF4Kruppel like factor 4. (510 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (701 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
CD63Tetraspanin. (237 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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