18 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NCOA4	Uncharacterized protein. (626 aa)
	PHB2	Prohibitin. (289 aa)
	DHFR	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa)
	ACTB	Uncharacterized protein. (375 aa)
	VDAC2	Voltage dependent anion channel 2. (294 aa)
	GOT2	Aspartate aminotransferase. (430 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	DHODH	Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (395 aa)
	FTH1	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (181 aa)
	ALB	Serum albumin. (608 aa)
	TFRC	Transferrin receptor. (790 aa)
	FTL	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (175 aa)
	GOT1	Aspartate aminotransferase. (413 aa)
	VDAC1	Voltage dependent anion channel 1. (283 aa)
	GPX4	Uncharacterized protein. (190 aa)
	EPHB2	EPH receptor B2. (1016 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	GCH1	GTP cyclohydrolase 1. (248 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	EPHB2	ENSCHIP00000011080	ENSCHIP00000026488	Uncharacterized protein.	EPH receptor B2.	0.403
ACTB	FTH1	ENSCHIP00000011080	ENSCHIP00000020262	Uncharacterized protein.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	0.551
ACTB	FTL	ENSCHIP00000011080	ENSCHIP00000030044	Uncharacterized protein.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.	0.401
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	GOT1	ENSCHIP00000011080	ENSCHIP00000029101	Uncharacterized protein.	Aspartate aminotransferase.	0.779
ACTB	GOT2	ENSCHIP00000011080	ENSCHIP00000010968	Uncharacterized protein.	Aspartate aminotransferase.	0.779
ACTB	GPX4	ENSCHIP00000011080	ENSCHIP00000028055	Uncharacterized protein.	Uncharacterized protein.	0.718
ACTB	PHB2	ENSCHIP00000011080	ENSCHIP00000017241	Uncharacterized protein.	Prohibitin.	0.639
ACTB	TFRC	ENSCHIP00000011080	ENSCHIP00000033446	Uncharacterized protein.	Transferrin receptor.	0.734
ACTB	TNF	ENSCHIP00000011080	ENSCHIP00000004561	Uncharacterized protein.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.886
ACTB	VDAC1	ENSCHIP00000011080	ENSCHIP00000028854	Uncharacterized protein.	Voltage dependent anion channel 1.	0.742
ALB	ACTB	ENSCHIP00000020234	ENSCHIP00000011080	Serum albumin.	Uncharacterized protein.	0.961
ALB	DHFR	ENSCHIP00000020234	ENSCHIP00000015609	Serum albumin.	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	0.474
ALB	GAPDH	ENSCHIP00000020234	ENSCHIP00000025974	Serum albumin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.948
ALB	GOT1	ENSCHIP00000020234	ENSCHIP00000029101	Serum albumin.	Aspartate aminotransferase.	0.972
ALB	GOT2	ENSCHIP00000020234	ENSCHIP00000010968	Serum albumin.	Aspartate aminotransferase.	0.954
ALB	GPX4	ENSCHIP00000020234	ENSCHIP00000028055	Serum albumin.	Uncharacterized protein.	0.428
ALB	PHB2	ENSCHIP00000020234	ENSCHIP00000017241	Serum albumin.	Prohibitin.	0.430
ALB	TFRC	ENSCHIP00000020234	ENSCHIP00000033446	Serum albumin.	Transferrin receptor.	0.752