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GJA3 GJA3 GJB2 GJB2 CA12 CA12 SPAG8 SPAG8 RXFP2 RXFP2 CTLA4 CTLA4 NPR2 NPR2 OSMR OSMR DAB2 DAB2 HINT2 HINT2 GNG2 GNG2 PLXNC1 PLXNC1 TRHDE TRHDE MSRB3 MSRB3 JADE2 JADE2 RMI1 RMI1 BMP2 BMP2 IL1R1 IL1R1 IL7 IL7 GRIA1 GRIA1 INSR INSR CAPSL CAPSL PROKR1 PROKR1 RAD1 RAD1 ITPR2 ITPR2 CYFIP1 CYFIP1 BMPR1B BMPR1B PLCB1 PLCB1 SAYSD1 SAYSD1 TSHR TSHR ZNF609 ZNF609 GATA6 GATA6 HIF3A HIF3A GNGT1 GNGT1 RAB8B RAB8B APH1B APH1B USP3 USP3 ALDH1A3 ALDH1A3 IL7R IL7R SPP2 SPP2 BMP4 BMP4 CDS2 CDS2 SOX6 SOX6 MITF MITF DNAJC18 DNAJC18 PTGER4 PTGER4 GNAI3 GNAI3 IL2 IL2 FAM162A FAM162A ICOS ICOS PTGDR PTGDR SLC26A4 SLC26A4 HOXB13 HOXB13 TRPM8 TRPM8 SOCS2 SOCS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GJA3Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (412 aa)
GJB2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (226 aa)
CA12Carbonic anhydrase 12; Belongs to the alpha-carbonic anhydrase family. (342 aa)
SPAG8Uncharacterized protein. (368 aa)
RXFP2Relaxin family peptide receptor 2. (725 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (221 aa)
NPR2Guanylate cyclase. (1047 aa)
OSMROncostatin M receptor. (948 aa)
DAB2DAB adaptor protein 2. (768 aa)
HINT2Histidine triad nucleotide binding protein 2. (163 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
PLXNC1Plexin C1. (1585 aa)
TRHDEThyrotropin releasing hormone degrading enzyme. (1063 aa)
MSRB3Peptide-methionine (R)-S-oxide reductase; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. (191 aa)
JADE2Jade family PHD finger 2. (861 aa)
RMI1RecQ mediated genome instability 1. (624 aa)
BMP2TGF_BETA_2 domain-containing protein. (381 aa)
IL1R1Interleukin 1 receptor type 1. (573 aa)
IL7Interleukin 7. (181 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
INSRTyrosine-protein kinase receptor. (1365 aa)
CAPSLCalcyphosine like. (208 aa)
PROKR1Prokineticin receptor 1; Belongs to the G-protein coupled receptor 1 family. (393 aa)
RAD1Uncharacterized protein. (279 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1268 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (558 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1115 aa)
SAYSD1SAYSVFN motif domain containing 1. (193 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (817 aa)
ZNF609Zinc finger protein 609. (1366 aa)
GATA6GATA binding protein 6. (592 aa)
HIF3AHypoxia inducible factor 3 subunit alpha. (694 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
RAB8BRAB8B, member RAS oncogene family. (207 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (257 aa)
USP3Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (520 aa)
ALDH1A3Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
IL7RInterleukin 7 receptor. (459 aa)
SPP2Secreted phosphoprotein 2. (224 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CDS2Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (445 aa)
SOX6SRY-box transcription factor 6. (858 aa)
MITFMelanocyte inducing transcription factor. (519 aa)
DNAJC18DnaJ heat shock protein family (Hsp40) member C18. (358 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (513 aa)
GNAI3G protein subunit alpha i3. (354 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
FAM162AFamily with sequence similarity 162 member A. (154 aa)
ICOSInducible T cell costimulator. (209 aa)
PTGDRProstaglandin D2 receptor. (361 aa)
SLC26A4Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (781 aa)
HOXB13Homeobox B13. (285 aa)
TRPM8Transient receptor potential cation channel subfamily M member 8. (1099 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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