25 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	PSAT1	Phosphoserine aminotransferase. (370 aa)
	EXOC4	Uncharacterized protein. (408 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
	NAGK	N-acetylglucosamine kinase. (344 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (502 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (768 aa)
	PSPH	Phosphoserine phosphatase. (225 aa)
	COL2A1	Collagen type II alpha 1 chain. (1259 aa)
	MYOD1	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (732 aa)
	AK1	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (194 aa)
	ATP6V0E2	V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
	NOS3	Nitric oxide synthase; Produces nitric oxide (NO). (1193 aa)
	ACTB	Uncharacterized protein. (375 aa)
	TFAM	Transcription factor A, mitochondrial. (246 aa)
	MMP9	Uncharacterized protein. (709 aa)
	PGM3	Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family. (542 aa)
	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif 5. (934 aa)
	ACAN	Aggrecan. (2402 aa)
	MMP13	Matrix metallopeptidase 13. (472 aa)
	MYOG	Myogenin. (224 aa)
	SOX9	SRY-box transcription factor 9. (525 aa)
	MMP3	Matrix metallopeptidase 3. (477 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAN	ACTB	ENSCHIP00000023516	ENSCHIP00000011080	Aggrecan.	Uncharacterized protein.	0.742
ACAN	ADAMTS5	ENSCHIP00000023516	ENSCHIP00000020287	Aggrecan.	ADAM metallopeptidase with thrombospondin type 1 motif 5.	0.942
ACAN	COL2A1	ENSCHIP00000023516	ENSCHIP00000005497	Aggrecan.	Collagen type II alpha 1 chain.	0.970
ACAN	GAPDH	ENSCHIP00000023516	ENSCHIP00000025974	Aggrecan.	Glyceraldehyde-3-phosphate dehydrogenase.	0.832
ACAN	IL1B	ENSCHIP00000023516	ENSCHIP00000029274	Aggrecan.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.813
ACAN	MMP13	ENSCHIP00000023516	ENSCHIP00000023527	Aggrecan.	Matrix metallopeptidase 13.	0.940
ACAN	MMP3	ENSCHIP00000023516	ENSCHIP00000026267	Aggrecan.	Matrix metallopeptidase 3.	0.923
ACAN	MMP9	ENSCHIP00000023516	ENSCHIP00000016938	Aggrecan.	Uncharacterized protein.	0.779
ACAN	SIRT1	ENSCHIP00000023516	ENSCHIP00000007571	Aggrecan.	Deacetylase sirtuin-type domain-containing protein.	0.413
ACAN	SOX9	ENSCHIP00000023516	ENSCHIP00000024523	Aggrecan.	SRY-box transcription factor 9.	0.946
ACTB	ACAN	ENSCHIP00000011080	ENSCHIP00000023516	Uncharacterized protein.	Aggrecan.	0.742
ACTB	ADAMTS5	ENSCHIP00000011080	ENSCHIP00000020287	Uncharacterized protein.	ADAM metallopeptidase with thrombospondin type 1 motif 5.	0.548
ACTB	COL2A1	ENSCHIP00000011080	ENSCHIP00000005497	Uncharacterized protein.	Collagen type II alpha 1 chain.	0.646
ACTB	CUL3	ENSCHIP00000011080	ENSCHIP00000003951	Uncharacterized protein.	Cullin 3; Belongs to the cullin family.	0.554
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	IL1B	ENSCHIP00000011080	ENSCHIP00000029274	Uncharacterized protein.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.918
ACTB	MMP13	ENSCHIP00000011080	ENSCHIP00000023527	Uncharacterized protein.	Matrix metallopeptidase 13.	0.722
ACTB	MMP3	ENSCHIP00000011080	ENSCHIP00000026267	Uncharacterized protein.	Matrix metallopeptidase 3.	0.755
ACTB	MMP9	ENSCHIP00000011080	ENSCHIP00000016938	Uncharacterized protein.	Uncharacterized protein.	0.881
ACTB	MYOD1	ENSCHIP00000011080	ENSCHIP00000005799	Uncharacterized protein.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.660