48 items (Capra hircus) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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protein homology

Your Input:
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	ACSL4	Acyl-CoA synthetase long chain family member 4. (711 aa)
	MAPK14	Mitogen-activated protein kinase. (350 aa)
	SLC27A5	Solute carrier family 27 member 5. (690 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
	SLC25A20	Solute carrier family 25 member 20; Belongs to the mitochondrial carrier (TC 2.A.29) family. (301 aa)
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
	ACADL	Acyl-CoA dehydrogenase long chain. (430 aa)
	LOC102190925	Uncharacterized protein. (419 aa)
	ELOVL5	Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa)
	ACTB	Uncharacterized protein. (375 aa)
	MAPK4	Mitogen-activated protein kinase 4. (588 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (780 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	TSC2	Rap-GAP domain-containing protein. (1817 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2329 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
	PXDN	Peroxidasin. (1525 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
	ECI2	Enoyl-CoA delta isomerase 2. (426 aa)
	MAPK12	Mitogen-activated protein kinase 12. (359 aa)
	ELOVL4	Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane [...] (314 aa)
	FASN	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2755 aa)
	MAPK11	Mitogen-activated protein kinase. (417 aa)
	ALB	Serum albumin. (608 aa)
	ACSL5	Acyl-CoA synthetase long chain family member 5. (683 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	ELOVL3	Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] (270 aa)
	ACAT1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (409 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (397 aa)
	OXSM	3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (460 aa)
	ACSL3	Acyl-CoA synthetase long chain family member 3. (720 aa)
	ALDH9A1	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (494 aa)
	MAPK15	Mitogen-activated protein kinase. (543 aa)
	ACSL1	Acyl-CoA synthetase long chain family member 1. (719 aa)
	HADHA	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
	DGAT1	O-acyltransferase. (490 aa)
	MAPK13	Mitogen-activated protein kinase. (366 aa)
	XBP1	BZIP domain-containing protein. (261 aa)
	ACOT7	Acyl-CoA thioesterase 7. (385 aa)
	HADHB	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (475 aa)
	PPT1	Palmitoyl-protein thioesterase 1. (306 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	CD36	Uncharacterized protein; Belongs to the CD36 family. (472 aa)
	CPT1C	Carnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (796 aa)
	MAPK8	Mitogen-activated protein kinase. (442 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1507 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (470 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACADL	ENSCHIP00000013374	ENSCHIP00000009763	Acetyl-CoA carboxylase alpha.	Acyl-CoA dehydrogenase long chain.	0.624
ACACA	ACAT1	ENSCHIP00000013374	ENSCHIP00000023794	Acetyl-CoA carboxylase alpha.	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.977
ACACA	ACSL1	ENSCHIP00000013374	ENSCHIP00000026081	Acetyl-CoA carboxylase alpha.	Acyl-CoA synthetase long chain family member 1.	0.894
ACACA	ACSL3	ENSCHIP00000013374	ENSCHIP00000024361	Acetyl-CoA carboxylase alpha.	Acyl-CoA synthetase long chain family member 3.	0.745
ACACA	ACSL4	ENSCHIP00000013374	ENSCHIP00000000112	Acetyl-CoA carboxylase alpha.	Acyl-CoA synthetase long chain family member 4.	0.540
ACACA	ACSL5	ENSCHIP00000013374	ENSCHIP00000021425	Acetyl-CoA carboxylase alpha.	Acyl-CoA synthetase long chain family member 5.	0.534
ACACA	ACTB	ENSCHIP00000013374	ENSCHIP00000011080	Acetyl-CoA carboxylase alpha.	Uncharacterized protein.	0.512
ACACA	ALB	ENSCHIP00000013374	ENSCHIP00000020234	Acetyl-CoA carboxylase alpha.	Serum albumin.	0.451
ACACA	CD36	ENSCHIP00000013374	ENSCHIP00000030240	Acetyl-CoA carboxylase alpha.	Uncharacterized protein; Belongs to the CD36 family.	0.717
ACACA	DGAT1	ENSCHIP00000013374	ENSCHIP00000026908	Acetyl-CoA carboxylase alpha.	O-acyltransferase.	0.810
ACACA	ECI2	ENSCHIP00000013374	ENSCHIP00000015615	Acetyl-CoA carboxylase alpha.	Enoyl-CoA delta isomerase 2.	0.526
ACACA	ELOVL3	ENSCHIP00000013374	ENSCHIP00000022685	Acetyl-CoA carboxylase alpha.	Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...]	0.418
ACACA	ELOVL5	ENSCHIP00000013374	ENSCHIP00000010413	Acetyl-CoA carboxylase alpha.	Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...]	0.641
ACACA	FASN	ENSCHIP00000013374	ENSCHIP00000019407	Acetyl-CoA carboxylase alpha.	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	0.994
ACACA	GAPDH	ENSCHIP00000013374	ENSCHIP00000025974	Acetyl-CoA carboxylase alpha.	Glyceraldehyde-3-phosphate dehydrogenase.	0.498
ACACA	HADHA	ENSCHIP00000013374	ENSCHIP00000026358	Acetyl-CoA carboxylase alpha.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha; Belongs to the enoyl-CoA hydratase/isomerase family.	0.600
ACACA	HADHB	ENSCHIP00000013374	ENSCHIP00000029745	Acetyl-CoA carboxylase alpha.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family.	0.497
ACACA	LOC102190925	ENSCHIP00000013374	ENSCHIP00000010386	Acetyl-CoA carboxylase alpha.	Uncharacterized protein.	0.560
ACACA	OXSM	ENSCHIP00000013374	ENSCHIP00000024300	Acetyl-CoA carboxylase alpha.	3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.800
ACACA	PPARA	ENSCHIP00000013374	ENSCHIP00000032439	Acetyl-CoA carboxylase alpha.	Peroxisome proliferator activated receptor alpha.	0.684