35 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108636012	Histone H3; Belongs to the histone H3 family. (136 aa)
	H3-4	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC108634231	Histone H3; Belongs to the histone H3 family. (136 aa)
	PSPH	Phosphoserine phosphatase. (225 aa)
	LOC102180554	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC106503499	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC108633916	Histone H3; Belongs to the histone H3 family. (136 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (732 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
	LOC102171353	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC102169981	Histone domain-containing protein. (136 aa)
	HDAC7	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1062 aa)
	ACTB	Uncharacterized protein. (375 aa)
	SHMT1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
	SOD1	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
	ATF4	Activating transcription factor 4. (352 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	BMI1	RING-type domain-containing protein. (437 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1142 aa)
	PHGDH	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
	HDAC4	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1089 aa)
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (390 aa)
	EGFR	Receptor protein-tyrosine kinase. (1208 aa)
	LOC102189503	Histone H3; Belongs to the histone H3 family. (136 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	PSAT1	Phosphoserine aminotransferase. (370 aa)
	HDAC9	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1069 aa)
	SIRT6	Sirtuin 6. (335 aa)
	ADIPOQ	C1q domain-containing protein. (283 aa)
	LOC102191748	Histone domain-containing protein. (136 aa)
	LOC102185882	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC108633554	Histone domain-containing protein. (136 aa)
	LOC102182848	Histone H3; Belongs to the histone H3 family. (136 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ADIPOQ	ENSCHIP00000011080	ENSCHIP00000032803	Uncharacterized protein.	C1q domain-containing protein.	0.751
ACTB	ATF4	ENSCHIP00000011080	ENSCHIP00000013483	Uncharacterized protein.	Activating transcription factor 4.	0.683
ACTB	BMI1	ENSCHIP00000011080	ENSCHIP00000016491	Uncharacterized protein.	RING-type domain-containing protein.	0.697
ACTB	CASP3	ENSCHIP00000011080	ENSCHIP00000011490	Uncharacterized protein.	Caspase 3; Belongs to the peptidase C14A family.	0.996
ACTB	EGFR	ENSCHIP00000011080	ENSCHIP00000022759	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.891
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	H3-4	ENSCHIP00000011080	ENSCHIP00000004038	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.904
ACTB	HDAC4	ENSCHIP00000011080	ENSCHIP00000019494	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.626
ACTB	HDAC7	ENSCHIP00000011080	ENSCHIP00000009920	Uncharacterized protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.419
ACTB	INS	ENSCHIP00000011080	ENSCHIP00000007610	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.884
ACTB	LOC102169981	ENSCHIP00000011080	ENSCHIP00000008812	Uncharacterized protein.	Histone domain-containing protein.	0.901
ACTB	LOC102171353	ENSCHIP00000011080	ENSCHIP00000008371	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.904
ACTB	LOC102180554	ENSCHIP00000011080	ENSCHIP00000006161	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.920
ACTB	LOC102182848	ENSCHIP00000011080	ENSCHIP00000002894	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.904
ACTB	LOC102185882	ENSCHIP00000011080	ENSCHIP00000001379	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.920
ACTB	LOC102189503	ENSCHIP00000011080	ENSCHIP00000024908	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.920
ACTB	LOC102191748	ENSCHIP00000011080	ENSCHIP00000000846	Uncharacterized protein.	Histone domain-containing protein.	0.904
ACTB	LOC106503499	ENSCHIP00000011080	ENSCHIP00000006566	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.920
ACTB	LOC108633554	ENSCHIP00000011080	ENSCHIP00000001940	Uncharacterized protein.	Histone domain-containing protein.	0.904
ACTB	LOC108633916	ENSCHIP00000011080	ENSCHIP00000006619	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.904