22 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SERPINH1	Serpin family H member 1; Belongs to the serpin family. (418 aa)
	ITIH2	Inter-alpha-trypsin inhibitor heavy chain 2. (956 aa)
	CD68	CD68 molecule. (335 aa)
	CTSS	Cathepsin S; Belongs to the peptidase C1 family. (331 aa)
	COL14A1	Collagen type XIV alpha 1 chain. (1775 aa)
	PLEC	Plectin. (4150 aa)
	COL4A1	Collagen type IV alpha 1 chain. (1608 aa)
	APOE	Apolipoprotein E. (326 aa)
	LOXL1	Lysyl oxidase like 1. (592 aa)
	LDLR	Low density lipoprotein receptor. (787 aa)
	COL6A3	Collagen type VI alpha 3 chain. (3111 aa)
	ACTA2	Actin alpha 2, smooth muscle. (377 aa)
	LOX	Lysyl oxidase. (418 aa)
	ITIH4	Inter-alpha-trypsin inhibitor heavy chain 4. (909 aa)
	ACTB	Uncharacterized protein. (375 aa)
	COL18A1	Endostatin domain-containing protein. (189 aa)
	PLG	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (816 aa)
	CTSD	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (412 aa)
	P4HB	Protein disulfide-isomerase. (565 aa)
	COL4A2	Collagen type IV alpha 2 chain. (1607 aa)
	CTSB	Cathepsin B; Belongs to the peptidase C1 family. (335 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTA2	CD68	ENSCHIP00000018506	ENSCHIP00000027336	Actin alpha 2, smooth muscle.	CD68 molecule.	0.512
ACTA2	COL4A1	ENSCHIP00000018506	ENSCHIP00000025370	Actin alpha 2, smooth muscle.	Collagen type IV alpha 1 chain.	0.505
ACTA2	COL4A2	ENSCHIP00000018506	ENSCHIP00000032096	Actin alpha 2, smooth muscle.	Collagen type IV alpha 2 chain.	0.439
ACTA2	LOX	ENSCHIP00000018506	ENSCHIP00000017017	Actin alpha 2, smooth muscle.	Lysyl oxidase.	0.432
ACTA2	LOXL1	ENSCHIP00000018506	ENSCHIP00000024431	Actin alpha 2, smooth muscle.	Lysyl oxidase like 1.	0.405
ACTB	APOE	ENSCHIP00000011080	ENSCHIP00000025098	Uncharacterized protein.	Apolipoprotein E.	0.753
ACTB	CD68	ENSCHIP00000011080	ENSCHIP00000027336	Uncharacterized protein.	CD68 molecule.	0.791
ACTB	CTSB	ENSCHIP00000011080	ENSCHIP00000030835	Uncharacterized protein.	Cathepsin B; Belongs to the peptidase C1 family.	0.705
ACTB	CTSD	ENSCHIP00000011080	ENSCHIP00000002434	Uncharacterized protein.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.705
ACTB	CTSS	ENSCHIP00000011080	ENSCHIP00000026412	Uncharacterized protein.	Cathepsin S; Belongs to the peptidase C1 family.	0.628
ACTB	LOX	ENSCHIP00000011080	ENSCHIP00000017017	Uncharacterized protein.	Lysyl oxidase.	0.693
ACTB	P4HB	ENSCHIP00000011080	ENSCHIP00000032640	Uncharacterized protein.	Protein disulfide-isomerase.	0.582
ACTB	PLG	ENSCHIP00000011080	ENSCHIP00000007843	Uncharacterized protein.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.536
APOE	ACTB	ENSCHIP00000025098	ENSCHIP00000011080	Apolipoprotein E.	Uncharacterized protein.	0.753
APOE	CD68	ENSCHIP00000025098	ENSCHIP00000027336	Apolipoprotein E.	CD68 molecule.	0.929
APOE	CTSB	ENSCHIP00000025098	ENSCHIP00000030835	Apolipoprotein E.	Cathepsin B; Belongs to the peptidase C1 family.	0.566
APOE	CTSD	ENSCHIP00000025098	ENSCHIP00000002434	Apolipoprotein E.	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.	0.560
APOE	CTSS	ENSCHIP00000025098	ENSCHIP00000026412	Apolipoprotein E.	Cathepsin S; Belongs to the peptidase C1 family.	0.498
APOE	LDLR	ENSCHIP00000025098	ENSCHIP00000021255	Apolipoprotein E.	Low density lipoprotein receptor.	0.425
APOE	LOX	ENSCHIP00000025098	ENSCHIP00000017017	Apolipoprotein E.	Lysyl oxidase.	0.464