39 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCND3	Cyclin D3; Belongs to the cyclin family. (292 aa)
	KRAS	KRAS proto-oncogene, GTPase. (189 aa)
	CDKN2A	Cyclin dependent kinase inhibitor 2A. (157 aa)
	CDKN2B	Cyclin dependent kinase inhibitor 2B. (138 aa)
	NKX1-1	NK1 homeobox 1. (375 aa)
	NKX2-2	NK2 homeobox 2. (273 aa)
	PFKP	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (791 aa)
	NKX2-1	NK2 homeobox 1. (370 aa)
	NKX6-1	NK6 homeobox 1. (367 aa)
	TAL1	TAL bHLH transcription factor 1, erythroid differentiation factor. (328 aa)
	PSAT1	Phosphoserine aminotransferase. (370 aa)
	NKX2-6	NK2 homeobox 6. (300 aa)
	SPTLC2	Serine palmitoyltransferase long chain base subunit 2. (562 aa)
	NOTCH1	Notch receptor 1. (2508 aa)
	NKX2-8	NK2 homeobox 8. (237 aa)
	LMO1	LIM domain only 1. (155 aa)
	CDK4	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
	LOC102190507	Uncharacterized protein. (139 aa)
	NKX2-3	NK2 homeobox 3. (367 aa)
	NKX2-5	NK2 homeobox 5. (323 aa)
	TLX1	T cell leukemia homeobox 1. (333 aa)
	NKX2-4	NK2 homeobox 4. (347 aa)
	SPTLC1	Serine palmitoyltransferase long chain base subunit 1. (480 aa)
	PKM	Pyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
	ATF3	Activating transcription factor 3. (181 aa)
	SHMT1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
	ACTB	Uncharacterized protein. (375 aa)
	PHF6	PHD finger protein 6. (366 aa)
	NKX3-2	NK3 homeobox 2. (330 aa)
	NKX3-1	NK3 homeobox 1. (239 aa)
	NKX1-2	NK1 homeobox 2. (301 aa)
	PSPH	Phosphoserine phosphatase. (225 aa)
	SPTLC3	Serine palmitoyltransferase long chain base subunit 3. (549 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
	PKLR	Pyruvate kinase; Belongs to the pyruvate kinase family. (575 aa)
	NKX6-3	Homeobox domain-containing protein. (263 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (502 aa)
	NKX6-2	NK6 homeobox 2. (286 aa)
	VCL	Vinculin. (1134 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ATF3	ENSCHIP00000011080	ENSCHIP00000014267	Uncharacterized protein.	Activating transcription factor 3.	0.608
ACTB	CCND3	ENSCHIP00000011080	ENSCHIP00000033357	Uncharacterized protein.	Cyclin D3; Belongs to the cyclin family.	0.681
ACTB	CDK4	ENSCHIP00000011080	ENSCHIP00000022710	Uncharacterized protein.	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	0.824
ACTB	CDKN2A	ENSCHIP00000011080	ENSCHIP00000031674	Uncharacterized protein.	Cyclin dependent kinase inhibitor 2A.	0.546
ACTB	KRAS	ENSCHIP00000011080	ENSCHIP00000032733	Uncharacterized protein.	KRAS proto-oncogene, GTPase.	0.795
ACTB	LOC102190507	ENSCHIP00000011080	ENSCHIP00000018311	Uncharacterized protein.	Uncharacterized protein.	0.658
ACTB	NOTCH1	ENSCHIP00000011080	ENSCHIP00000023681	Uncharacterized protein.	Notch receptor 1.	0.775
ACTB	PFKP	ENSCHIP00000011080	ENSCHIP00000030216	Uncharacterized protein.	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	0.663
ACTB	PKM	ENSCHIP00000011080	ENSCHIP00000015417	Uncharacterized protein.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.744
ACTB	PTEN	ENSCHIP00000011080	ENSCHIP00000002897	Uncharacterized protein.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.844
ACTB	SPTLC1	ENSCHIP00000011080	ENSCHIP00000016451	Uncharacterized protein.	Serine palmitoyltransferase long chain base subunit 1.	0.414
ACTB	VCL	ENSCHIP00000011080	ENSCHIP00000000453	Uncharacterized protein.	Vinculin.	0.988
ATF3	ACTB	ENSCHIP00000014267	ENSCHIP00000011080	Activating transcription factor 3.	Uncharacterized protein.	0.608
CCND3	ACTB	ENSCHIP00000033357	ENSCHIP00000011080	Cyclin D3; Belongs to the cyclin family.	Uncharacterized protein.	0.681
CCND3	CDK4	ENSCHIP00000033357	ENSCHIP00000022710	Cyclin D3; Belongs to the cyclin family.	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	0.999
CCND3	CDKN2A	ENSCHIP00000033357	ENSCHIP00000031674	Cyclin D3; Belongs to the cyclin family.	Cyclin dependent kinase inhibitor 2A.	0.605
CCND3	CDKN2B	ENSCHIP00000033357	ENSCHIP00000031534	Cyclin D3; Belongs to the cyclin family.	Cyclin dependent kinase inhibitor 2B.	0.963
CCND3	NOTCH1	ENSCHIP00000033357	ENSCHIP00000023681	Cyclin D3; Belongs to the cyclin family.	Notch receptor 1.	0.440
CCND3	PTEN	ENSCHIP00000033357	ENSCHIP00000002897	Cyclin D3; Belongs to the cyclin family.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.480
CDK4	ACTB	ENSCHIP00000022710	ENSCHIP00000011080	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.824