Uncharacterized protein.

Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]

Uncharacterized protein.

ATRX chromatin remodeler.

Uncharacterized protein.

FA complementation group D2.

Uncharacterized protein.

Glyceraldehyde-3-phosphate dehydrogenase.

Uncharacterized protein.

Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Uncharacterized protein.

Poly [ADP-ribose] polymerase.

Uncharacterized protein.

RAD52 homolog, DNA repair protein.

Uncharacterized protein.

Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]

Uncharacterized protein.

DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]

Uncharacterized protein.

DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.

Uncharacterized protein.

Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.

Uncharacterized protein.

X-ray repair cross complementing 1.

Anti-silencing function 1A histone chaperone.

Uncharacterized protein.

Anti-silencing function 1A histone chaperone.

ATRX chromatin remodeler.

Anti-silencing function 1A histone chaperone.

Daxx domain-containing protein.

Anti-silencing function 1A histone chaperone.

Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.

Anti-silencing function 1A histone chaperone.

RAD52 homolog, DNA repair protein.

Uncharacterized protein.

Anti-silencing function 1A histone chaperone.

Uncharacterized protein.

ATRX chromatin remodeler.

Uncharacterized protein.

Daxx domain-containing protein.