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ACLY ACLY CDC25A CDC25A ANGPTL4 ANGPTL4 ACSS2 ACSS2 LOC102182683 LOC102182683 IGFBP3 IGFBP3 TP53 TP53 CERS3 CERS3 CTNNB1 CTNNB1 LPL LPL MAB21L4 MAB21L4 CDK1 CDK1 PTEN PTEN CDK2 CDK2 TNF TNF AGO2 AGO2 CCND1 CCND1 IL6 IL6 ACTB ACTB ADAM17 ADAM17 SMAD3 SMAD3 CXCL10 CXCL10 CCL20 CCL20 PPARG PPARG PXDN PXDN NOTCH3 NOTCH3 IL22 IL22 FASN FASN SMAD4 SMAD4 MTOR MTOR SMAD2 SMAD2 STAT3 STAT3 NOTCH1 NOTCH1 DROSHA DROSHA PDCD4 PDCD4 GAPDH GAPDH TIMP3 TIMP3 MMP3 MMP3 PLK1 PLK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa)
CDC25ACell division cycle 25A. (517 aa)
ANGPTL4Angiopoietin like 4. (413 aa)
ACSS2Acyl-CoA synthetase short chain family member 2. (714 aa)
LOC102182683C-X-C motif chemokine. (109 aa)
IGFBP3Uncharacterized protein. (293 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
CERS3Ceramide synthase 3. (387 aa)
CTNNB1Catenin beta 1. (781 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (487 aa)
MAB21L4Mab-21 like 4. (437 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (312 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
CDK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (860 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
ACTBUncharacterized protein. (375 aa)
ADAM17ADAM metallopeptidase domain 17. (829 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
CXCL10C-X-C motif chemokine. (102 aa)
CCL20C-C motif chemokine. (96 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
PXDNPeroxidasin. (1525 aa)
NOTCH3Notch receptor 3. (2332 aa)
IL22Interleukin 22. (190 aa)
FASNFatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2755 aa)
SMAD4Mothers against decapentaplegic homolog. (513 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
NOTCH1Notch receptor 1. (2508 aa)
DROSHADrosha ribonuclease III. (1371 aa)
PDCD4Programmed cell death 4. (513 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
TIMP3Tissue inhibitor of metalloproteinase 3 protein. (211 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
PLK1Serine/threonine-protein kinase PLK. (602 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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