STRINGSTRING
SMAD3 SMAD3 TP53 TP53 MMUT MMUT GAPDH GAPDH ZEB2 ZEB2 EIF4H EIF4H STAT3 STAT3 SMAD2 SMAD2 MDM2 MDM2 BRAF BRAF MMP9 MMP9 ZEB1 ZEB1 TEAD1 TEAD1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD3Mothers against decapentaplegic homolog. (425 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
MMUTMethylmalonyl-CoA mutase. (771 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1214 aa)
EIF4HEukaryotic translation initiation factor 4H. (214 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (774 aa)
MMP9Uncharacterized protein. (709 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1127 aa)
TEAD1TEA domain transcription factor 1. (436 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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