(19 nodes) (2023) Anti-tumor properties of FoxO1 in YD-9 oral squamous cell carcinoma cells. network (Capra hircus)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	CTNNB1	Catenin beta 1. (781 aa)
	BECN1	Uncharacterized protein. (448 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
	PRDX5	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (216 aa)
	ACTB	Uncharacterized protein. (375 aa)
	CCL20	C-C motif chemokine. (96 aa)
	KRT80	Keratin 80; Belongs to the intermediate filament family. (451 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	PXDN	Peroxidasin. (1525 aa)
	KRT76	Keratin 76; Belongs to the intermediate filament family. (562 aa)
	FOXO1	Forkhead box O1. (668 aa)
	FOXO3	Forkhead box O3. (672 aa)
	PRDX3	Peroxiredoxin 3. (257 aa)
	ALB	Serum albumin. (608 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	KRT10	Keratin 10; Belongs to the intermediate filament family. (564 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	SQSTM1	Sequestosome 1. (440 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	BECN1	ENSCHIP00000011080	ENSCHIP00000024304	Uncharacterized protein.	Uncharacterized protein.	0.886
ACTB	CCL20	ENSCHIP00000011080	ENSCHIP00000014421	Uncharacterized protein.	C-C motif chemokine.	0.570
ACTB	CDK5	ENSCHIP00000011080	ENSCHIP00000031665	Uncharacterized protein.	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	0.688
ACTB	CTNNB1	ENSCHIP00000011080	ENSCHIP00000031016	Uncharacterized protein.	Catenin beta 1.	0.906
ACTB	FOXO1	ENSCHIP00000011080	ENSCHIP00000018991	Uncharacterized protein.	Forkhead box O1.	0.791
ACTB	FOXO3	ENSCHIP00000011080	ENSCHIP00000019148	Uncharacterized protein.	Forkhead box O3.	0.685
ACTB	KRT10	ENSCHIP00000011080	ENSCHIP00000030287	Uncharacterized protein.	Keratin 10; Belongs to the intermediate filament family.	0.405
ACTB	PRDX3	ENSCHIP00000011080	ENSCHIP00000019739	Uncharacterized protein.	Peroxiredoxin 3.	0.452
ACTB	PXDN	ENSCHIP00000011080	ENSCHIP00000015493	Uncharacterized protein.	Peroxidasin.	0.962
ACTB	SQSTM1	ENSCHIP00000011080	ENSCHIP00000026704	Uncharacterized protein.	Sequestosome 1.	0.774
ACTB	STAT3	ENSCHIP00000011080	ENSCHIP00000022282	Uncharacterized protein.	Signal transducer and activator of transcription.	0.882
ACTB	TNF	ENSCHIP00000011080	ENSCHIP00000004561	Uncharacterized protein.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.886
ACTB	TP53	ENSCHIP00000011080	ENSCHIP00000030141	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.907
ALB	ACTB	ENSCHIP00000020234	ENSCHIP00000011080	Serum albumin.	Uncharacterized protein.	0.961
ALB	BECN1	ENSCHIP00000020234	ENSCHIP00000024304	Serum albumin.	Uncharacterized protein.	0.764
ALB	CCL20	ENSCHIP00000020234	ENSCHIP00000014421	Serum albumin.	C-C motif chemokine.	0.495
ALB	CDK5	ENSCHIP00000020234	ENSCHIP00000031665	Serum albumin.	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	0.534
ALB	CTNNB1	ENSCHIP00000020234	ENSCHIP00000031016	Serum albumin.	Catenin beta 1.	0.842
ALB	FOXO1	ENSCHIP00000020234	ENSCHIP00000018991	Serum albumin.	Forkhead box O1.	0.679