STRINGSTRING
ITGA1 ITGA1 COL1A1 COL1A1 COL4A1 COL4A1 FGF1 FGF1 CSF1R CSF1R ABCC9 ABCC9 COL4A2 COL4A2 CEBPB CEBPB LAMC3 LAMC3 PDGFB PDGFB COL1A2 COL1A2 PLP1 PLP1 PDGFRB PDGFRB IL1B IL1B THY1 THY1 ITGA7 ITGA7 TGFB2 TGFB2 GAPDH GAPDH TGFB3 TGFB3 PDGFRA PDGFRA CDKN1A CDKN1A ALDH1L1 ALDH1L1 ANPEP ANPEP CCND1 CCND1 LAMA4 LAMA4 NT5E NT5E MYH11 MYH11 LAMA2 LAMA2 TGFB1 TGFB1 MOBP MOBP COL5A2 COL5A2 TAGLN TAGLN ITGB5 ITGB5 ACTA2 ACTA2 ALB ALB ITGA4 ITGA4 CD48 CD48 SLC4A4 SLC4A4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1179 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
COL4A1Collagen type IV alpha 1 chain. (1608 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
CSF1RColony stimulating factor 1 receptor. (958 aa)
ABCC9ATP binding cassette subfamily C member 9. (1549 aa)
COL4A2Collagen type IV alpha 2 chain. (1607 aa)
CEBPBCCAAT/enhancer-binding protein. (307 aa)
LAMC3Laminin subunit gamma 3. (1575 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
COL1A2Collagen type I alpha 2 chain. (1128 aa)
PLP1Proteolipid protein 1. (277 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
THY1Thy-1 cell surface antigen. (161 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (161 aa)
ALDH1L110-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (899 aa)
ANPEPAminopeptidase. (973 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
LAMA4Laminin subunit alpha 4. (1824 aa)
NT5E5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1972 aa)
LAMA2Laminin subunit alpha 2. (3116 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
MOBPMyelin associated oligodendrocyte basic protein. (153 aa)
COL5A2Collagen type V alpha 2 chain. (1252 aa)
TAGLNTransgelin; Belongs to the calponin family. (201 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (802 aa)
ACTA2Actin alpha 2, smooth muscle. (377 aa)
ALBSerum albumin. (608 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
CD48Ig-like domain-containing protein. (236 aa)
SLC4A4Anion exchange protein. (1125 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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