(38 nodes) (2023) Pluripotent stem cell-derived committed cardiac progenitors remuscularize damaged ischemic hearts and improve their function in pigs. network (Capra hircus)

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Your Input:
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
	LOC102182848	Histone H3; Belongs to the histone H3 family. (136 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1390 aa)
	LOC108636012	Histone H3; Belongs to the histone H3 family. (136 aa)
	H3-4	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC108634231	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC102180554	Histone H3; Belongs to the histone H3 family. (136 aa)
	ACTN2	Actinin alpha 2. (902 aa)
	LOC106503499	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC102189503	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC108633554	Histone domain-containing protein. (136 aa)
	GJA1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (382 aa)
	LOC102185882	Histone H3; Belongs to the histone H3 family. (136 aa)
	CCDC80	Coiled-coil domain containing 80. (948 aa)
	LOC102191748	Histone domain-containing protein. (136 aa)
	KIT	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (974 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	IGFBP7	Insulin like growth factor binding protein 7. (282 aa)
	SLIT2-2	LRRNT domain-containing protein. (167 aa)
	SLIT2	Slit guidance ligand 2. (1457 aa)
	LOC108633916	Histone H3; Belongs to the histone H3 family. (136 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (116 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
	LOC102171353	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC102169981	Histone domain-containing protein. (136 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	MYL4	Myosin light chain 4. (193 aa)
	PXDN	Peroxidasin. (1525 aa)
	TNNI1	Troponin I1, slow skeletal type. (187 aa)
	MYH6	Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1943 aa)
	NKX2-5	NK2 homeobox 5. (323 aa)
	ANKRD1	Ankyrin repeat domain 1. (319 aa)
	VIM	Vimentin; Belongs to the intermediate filament family. (471 aa)
	TNNI3	Uncharacterized protein. (228 aa)
	ACTC1	Actin alpha cardiac muscle 1. (377 aa)
	TNNT2	Troponin T2, cardiac type. (267 aa)
	POU5F1	POU domain protein. (360 aa)
	SLC8A1	Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (650 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTC1	ACTN2	ENSCHIP00000002085	ENSCHIP00000006208	Actin alpha cardiac muscle 1.	Actinin alpha 2.	0.861
ACTC1	GJA1	ENSCHIP00000002085	ENSCHIP00000001879	Actin alpha cardiac muscle 1.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.413
ACTC1	MYH6	ENSCHIP00000002085	ENSCHIP00000017471	Actin alpha cardiac muscle 1.	Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.999
ACTC1	MYL4	ENSCHIP00000002085	ENSCHIP00000013903	Actin alpha cardiac muscle 1.	Myosin light chain 4.	0.976
ACTC1	NKX2-5	ENSCHIP00000002085	ENSCHIP00000017688	Actin alpha cardiac muscle 1.	NK2 homeobox 5.	0.554
ACTC1	TNNI1	ENSCHIP00000002085	ENSCHIP00000016174	Actin alpha cardiac muscle 1.	Troponin I1, slow skeletal type.	0.553
ACTC1	TNNI3	ENSCHIP00000002085	ENSCHIP00000022616	Actin alpha cardiac muscle 1.	Uncharacterized protein.	0.743
ACTC1	TNNT2	ENSCHIP00000002085	ENSCHIP00000022908	Actin alpha cardiac muscle 1.	Troponin T2, cardiac type.	0.817
ACTN2	ACTC1	ENSCHIP00000006208	ENSCHIP00000002085	Actinin alpha 2.	Actin alpha cardiac muscle 1.	0.861
ACTN2	ANKRD1	ENSCHIP00000006208	ENSCHIP00000019764	Actinin alpha 2.	Ankyrin repeat domain 1.	0.557
ACTN2	GJA1	ENSCHIP00000006208	ENSCHIP00000001879	Actinin alpha 2.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.543
ACTN2	MYH6	ENSCHIP00000006208	ENSCHIP00000017471	Actinin alpha 2.	Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.870
ACTN2	MYL4	ENSCHIP00000006208	ENSCHIP00000013903	Actinin alpha 2.	Myosin light chain 4.	0.666
ACTN2	NKX2-5	ENSCHIP00000006208	ENSCHIP00000017688	Actinin alpha 2.	NK2 homeobox 5.	0.811
ACTN2	SLC8A1	ENSCHIP00000006208	ENSCHIP00000024579	Actinin alpha 2.	Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.431
ACTN2	TNNI1	ENSCHIP00000006208	ENSCHIP00000016174	Actinin alpha 2.	Troponin I1, slow skeletal type.	0.861
ACTN2	TNNI3	ENSCHIP00000006208	ENSCHIP00000022616	Actinin alpha 2.	Uncharacterized protein.	0.859
ACTN2	TNNT2	ENSCHIP00000006208	ENSCHIP00000022908	Actinin alpha 2.	Troponin T2, cardiac type.	0.902
ACTN2	VIM	ENSCHIP00000006208	ENSCHIP00000022577	Actinin alpha 2.	Vimentin; Belongs to the intermediate filament family.	0.402
ANKRD1	ACTN2	ENSCHIP00000019764	ENSCHIP00000006208	Ankyrin repeat domain 1.	Actinin alpha 2.	0.557