45 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	JAK2	Tyrosine-protein kinase. (1132 aa)
	FABP4	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	STAT1	Signal transducer and activator of transcription. (834 aa)
	THRSP	Thyroid hormone responsive. (150 aa)
	PRP6	Prolactin-related protein-6. (239 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
	GH1	Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (217 aa)
	IGFBP5	Insulin-like growth factor binding protein 5. (272 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	LOC102170569	Uncharacterized protein. (211 aa)
	LOC102184390	Uncharacterized protein. (287 aa)
	LOC102190477	Uncharacterized protein. (238 aa)
	FABP3	Heart-type fatty acid binding protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2329 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	LOC102178616	Uncharacterized protein. (265 aa)
	LOC108638107	Uncharacterized protein. (238 aa)
	LTF	Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-\|- and -Arg-Arg-Ser-Arg-\|-, and of Z-Phe-Arg-\|-aminomethylcoumarin sites. (754 aa)
	LOC102190507	Uncharacterized protein. (139 aa)
	FASN	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2755 aa)
	LPIN1	Lipin 1. (913 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (844 aa)
	VLDLR	Very low density lipoprotein receptor. (873 aa)
	ACSS1	Acetyl-coenzyme A synthetase. (675 aa)
	PRP1	Prolactin-related protein-1. (238 aa)
	CSN2	Beta-casein; Important role in determination of the surface properties of the casein micelles. (228 aa)
	FABP5	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
	ACSL1	Acyl-CoA synthetase long chain family member 1. (719 aa)
	LOC102180550	Uncharacterized protein. (237 aa)
	LOC102171116	Uncharacterized protein. (226 aa)
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (278 aa)
	ACSS2	Acyl-CoA synthetase short chain family member 2. (714 aa)
	IGFBP3	Uncharacterized protein. (293 aa)
	SLC27A6	Solute carrier family 27 member 6. (634 aa)
	SREBF1	Uncharacterized protein. (68 aa)
	CD36	Uncharacterized protein; Belongs to the CD36 family. (472 aa)
	EPO	Erythropoietin. (208 aa)
	SERBP1	SERPINE1 mRNA binding protein 1. (401 aa)
	CSN3	Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk. (183 aa)
	SLC27A1	Solute carrier family 27 member 1. (646 aa)
	CSF2	Granulocyte-macrophage colony stimulating factor. (144 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (129 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACSL1	ENSCHIP00000013374	ENSCHIP00000026081	Acetyl-CoA carboxylase alpha.	Acyl-CoA synthetase long chain family member 1.	0.894
ACACA	ACSS1	ENSCHIP00000013374	ENSCHIP00000024627	Acetyl-CoA carboxylase alpha.	Acetyl-coenzyme A synthetase.	0.959
ACACA	ACSS2	ENSCHIP00000013374	ENSCHIP00000028459	Acetyl-CoA carboxylase alpha.	Acyl-CoA synthetase short chain family member 2.	0.983
ACACA	CD36	ENSCHIP00000013374	ENSCHIP00000030240	Acetyl-CoA carboxylase alpha.	Uncharacterized protein; Belongs to the CD36 family.	0.717
ACACA	CSN2	ENSCHIP00000013374	ENSCHIP00000024801	Acetyl-CoA carboxylase alpha.	Beta-casein; Important role in determination of the surface properties of the casein micelles.	0.422
ACACA	FABP3	ENSCHIP00000013374	ENSCHIP00000012241	Acetyl-CoA carboxylase alpha.	Heart-type fatty acid binding protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.795
ACACA	FABP4	ENSCHIP00000013374	ENSCHIP00000004118	Acetyl-CoA carboxylase alpha.	Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.	0.853
ACACA	FASN	ENSCHIP00000013374	ENSCHIP00000019407	Acetyl-CoA carboxylase alpha.	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	0.994
ACACA	GPAM	ENSCHIP00000013374	ENSCHIP00000022813	Acetyl-CoA carboxylase alpha.	Glycerol-3-phosphate acyltransferase 1, mitochondrial.	0.809
ACACA	INS	ENSCHIP00000013374	ENSCHIP00000007610	Acetyl-CoA carboxylase alpha.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.622
ACACA	INSIG1	ENSCHIP00000013374	ENSCHIP00000027402	Acetyl-CoA carboxylase alpha.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.754
ACACA	LPIN1	ENSCHIP00000013374	ENSCHIP00000019587	Acetyl-CoA carboxylase alpha.	Lipin 1.	0.865
ACACA	PPARG	ENSCHIP00000013374	ENSCHIP00000015163	Acetyl-CoA carboxylase alpha.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.728
ACACA	SLC27A1	ENSCHIP00000013374	ENSCHIP00000033688	Acetyl-CoA carboxylase alpha.	Solute carrier family 27 member 1.	0.463
ACACA	SLC27A6	ENSCHIP00000013374	ENSCHIP00000029374	Acetyl-CoA carboxylase alpha.	Solute carrier family 27 member 6.	0.518
ACACA	SREBF1	ENSCHIP00000013374	ENSCHIP00000029997	Acetyl-CoA carboxylase alpha.	Uncharacterized protein.	0.906
ACACA	THRSP	ENSCHIP00000013374	ENSCHIP00000006576	Acetyl-CoA carboxylase alpha.	Thyroid hormone responsive.	0.701
ACACA	VLDLR	ENSCHIP00000013374	ENSCHIP00000024369	Acetyl-CoA carboxylase alpha.	Very low density lipoprotein receptor.	0.462
ACSL1	ACACA	ENSCHIP00000026081	ENSCHIP00000013374	Acyl-CoA synthetase long chain family member 1.	Acetyl-CoA carboxylase alpha.	0.894
ACSL1	ACSS1	ENSCHIP00000026081	ENSCHIP00000024627	Acyl-CoA synthetase long chain family member 1.	Acetyl-coenzyme A synthetase.	0.741