33 items (Capra hircus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

Your Input:
	PLEK2	Pleckstrin 2. (354 aa)
	GFAP	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (428 aa)
	ACSS2	Acyl-CoA synthetase short chain family member 2. (714 aa)
	MAP1LC3B	Uncharacterized protein. (143 aa)
	POU1F1	Uncharacterized protein. (261 aa)
	MAPKAP1	MAPK associated protein 1. (522 aa)
	EEF1B2	Uncharacterized protein; Belongs to the EF-1-beta/EF-1-delta family. (225 aa)
	LAMP1	Lysosomal associated membrane protein 1. (409 aa)
	CTSD	Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (412 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (105 aa)
	EEF1D	Uncharacterized protein; Belongs to the EF-1-beta/EF-1-delta family. (280 aa)
	ACTB	Uncharacterized protein. (375 aa)
	TSG101	Uncharacterized protein. (391 aa)
	EEF2	Tr-type G domain-containing protein. (858 aa)
	INSR	Tyrosine-protein kinase receptor. (1365 aa)
	ACACA	Acetyl-CoA carboxylase alpha. (2329 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (557 aa)
	CIP2A	Cell proliferation regulating inhibitor of protein phosphatase 2A. (892 aa)
	ENO1	Enolase 1. (434 aa)
	HSPA8	Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
	PLEK	Pleckstrin. (356 aa)
	FASN	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2755 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (188 aa)
	ALB	Serum albumin. (608 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	ACACB	Acetyl-CoA carboxylase beta. (2448 aa)
	PHLPP1	PH domain and leucine rich repeat protein phosphatase 1. (1544 aa)
	EEF1G	Uncharacterized protein. (440 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	RICTOR	RPTOR independent companion of MTOR complex 2. (1707 aa)
	SQSTM1	Sequestosome 1. (440 aa)
	ACLY	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACACB	ENSCHIP00000013374	ENSCHIP00000022874	Acetyl-CoA carboxylase alpha.	Acetyl-CoA carboxylase beta.	0.943
ACACA	ACLY	ENSCHIP00000013374	ENSCHIP00000027213	Acetyl-CoA carboxylase alpha.	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	0.987
ACACA	ACSS2	ENSCHIP00000013374	ENSCHIP00000028459	Acetyl-CoA carboxylase alpha.	Acyl-CoA synthetase short chain family member 2.	0.983
ACACA	ACTB	ENSCHIP00000013374	ENSCHIP00000011080	Acetyl-CoA carboxylase alpha.	Uncharacterized protein.	0.512
ACACA	ALB	ENSCHIP00000013374	ENSCHIP00000020234	Acetyl-CoA carboxylase alpha.	Serum albumin.	0.451
ACACA	FASN	ENSCHIP00000013374	ENSCHIP00000019407	Acetyl-CoA carboxylase alpha.	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	0.994
ACACA	GAPDH	ENSCHIP00000013374	ENSCHIP00000025974	Acetyl-CoA carboxylase alpha.	Glyceraldehyde-3-phosphate dehydrogenase.	0.498
ACACA	INS	ENSCHIP00000013374	ENSCHIP00000007610	Acetyl-CoA carboxylase alpha.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.622
ACACB	ACACA	ENSCHIP00000022874	ENSCHIP00000013374	Acetyl-CoA carboxylase beta.	Acetyl-CoA carboxylase alpha.	0.943
ACACB	ACLY	ENSCHIP00000022874	ENSCHIP00000027213	Acetyl-CoA carboxylase beta.	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	0.976
ACACB	ACSS2	ENSCHIP00000022874	ENSCHIP00000028459	Acetyl-CoA carboxylase beta.	Acyl-CoA synthetase short chain family member 2.	0.937
ACACB	FASN	ENSCHIP00000022874	ENSCHIP00000019407	Acetyl-CoA carboxylase beta.	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	0.991
ACLY	ACACA	ENSCHIP00000027213	ENSCHIP00000013374	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Acetyl-CoA carboxylase alpha.	0.987
ACLY	ACACB	ENSCHIP00000027213	ENSCHIP00000022874	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Acetyl-CoA carboxylase beta.	0.976
ACLY	ACSS2	ENSCHIP00000027213	ENSCHIP00000028459	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Acyl-CoA synthetase short chain family member 2.	0.863
ACLY	ACTB	ENSCHIP00000027213	ENSCHIP00000011080	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Uncharacterized protein.	0.552
ACLY	ENO1	ENSCHIP00000027213	ENSCHIP00000015366	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Enolase 1.	0.460
ACLY	FASN	ENSCHIP00000027213	ENSCHIP00000019407	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein.	0.996
ACLY	GAPDH	ENSCHIP00000027213	ENSCHIP00000025974	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.555
ACLY	INS	ENSCHIP00000027213	ENSCHIP00000007610	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.573