STRINGSTRING
ANXA3 ANXA3 ANXA13 ANXA13 ENSCHIP00000009938 ENSCHIP00000009938 MSH3 MSH3 BRCA1 BRCA1 ANXA4 ANXA4 APEX1 APEX1 RAD50 RAD50 ANXA2 ANXA2 LIG4 LIG4 ANXA7 ANXA7 ANXA11 ANXA11 LOC102176495 LOC102176495 TOP3B TOP3B DDB1 DDB1 RAD51C RAD51C TDG TDG MGMT MGMT ANXA6 ANXA6 ATM ATM ERCC8 ERCC8 PMS2 PMS2 ALDH1A1 ALDH1A1 RAD51D RAD51D ENSCHIP00000022284 ENSCHIP00000022284 XRCC1 XRCC1 ANXA1 ANXA1 POU5F1 POU5F1 BRCA2 BRCA2 CD44 CD44 ANXA5 ANXA5 XRCC5 XRCC5 ERCC4 ERCC4 RAD23B RAD23B NEIL1 NEIL1 ERCC2 ERCC2 LOC108634039 LOC108634039 ANXA9 ANXA9 TOP1 TOP1 NEIL2 NEIL2 ERCC1 ERCC1 ACTB ACTB YY1 YY1 TOP3A TOP3A RAD51B RAD51B XPA XPA SOX2 SOX2 MUTYH MUTYH XAB2 XAB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANXA3Annexin. (323 aa)
ANXA13Annexin. (371 aa)
ENSCHIP00000009938Annexin. (100 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1119 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
ANXA4Annexin. (320 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
RAD50Zinc-hook domain-containing protein. (1332 aa)
ANXA2Annexin. (339 aa)
LIG4DNA ligase. (911 aa)
ANXA7Annexin. (485 aa)
ANXA11Annexin. (503 aa)
LOC102176495Annexin. (331 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (861 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
RAD51CRAD51 paralog C. (371 aa)
TDGThymine DNA glycosylase. (403 aa)
MGMTO-6-methylguanine-DNA methyltransferase. (222 aa)
ANXA6Annexin. (689 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (397 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (887 aa)
ALDH1A1Aldehyde dehydrogenase 1 family member A1; Belongs to the aldehyde dehydrogenase family. (501 aa)
RAD51DDNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (338 aa)
ENSCHIP00000022284Annexin. (275 aa)
XRCC1X-ray repair cross complementing 1. (632 aa)
ANXA1Annexin. (346 aa)
POU5F1POU domain protein. (360 aa)
BRCA2BRCA2 DNA repair associated. (3405 aa)
CD44CD44 molecule (Indian blood group). (715 aa)
ANXA5Annexin. (334 aa)
XRCC5X-ray repair cross complementing 5. (736 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (408 aa)
NEIL1Nei like DNA glycosylase 1. (390 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
LOC108634039Annexin. (449 aa)
ANXA9Annexin. (345 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa)
NEIL2Nei like DNA glycosylase 2. (336 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (294 aa)
ACTBUncharacterized protein. (375 aa)
YY1YY1 transcription factor. (415 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1002 aa)
RAD51BRAD51 paralog B. (270 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
SOX2HMG box domain-containing protein. (320 aa)
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (605 aa)
XAB2XPA binding protein 2. (892 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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