STRINGSTRING
PRDX4 PRDX4 PSAT1 PSAT1 TP53 TP53 SREBF1 SREBF1 USP7 USP7 GPX4 GPX4 BCORL1 BCORL1 MTR MTR LOC102191748 LOC102191748 LOC102174738 LOC102174738 MTHFD1 MTHFD1 LOC102185882 LOC102185882 SHMT2 SHMT2 LOC108633554 LOC108633554 SFXN2 SFXN2 LOC102182848 LOC102182848 EZH2 EZH2 LOC108636012 LOC108636012 SPTLC3 SPTLC3 ALDH1L1 ALDH1L1 H3-4 H3-4 LOC108634231 LOC108634231 GLS GLS PSPH PSPH PCGF1 PCGF1 TRIM27 TRIM27 AASS AASS LOC102180554 LOC102180554 LOC106503499 LOC106503499 LOC108633916 LOC108633916 CBS CBS LOC102171353 LOC102171353 LOC102169981 LOC102169981 GCLC GCLC SHMT1 SHMT1 TXN TXN ASNS ASNS ESRP1 ESRP1 ATF4 ATF4 ESRRA ESRRA SKP1 SKP1 MTFMT MTFMT PKM PKM PXDN PXDN RPIA RPIA GSR GSR FGF2 FGF2 PHGDH PHGDH CTH CTH MTOR MTOR EGFR EGFR MTHFD2 MTHFD2 LOC102189503 LOC102189503 GLDC GLDC SFXN1 SFXN1 SLC25A38 SLC25A38 KDM4C KDM4C RYBP RYBP MTHFR MTHFR NQO1 NQO1 SLC1A4 SLC1A4 GCLM GCLM BCAT1 BCAT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRDX4Peroxiredoxin 4. (275 aa)
PSAT1Phosphoserine aminotransferase. (370 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
SREBF1Uncharacterized protein. (68 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1103 aa)
GPX4Uncharacterized protein. (190 aa)
BCORL1BCL6 corepressor like 1. (1786 aa)
MTRMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1265 aa)
LOC102191748Histone domain-containing protein. (136 aa)
LOC102174738Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
MTHFD1Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (935 aa)
LOC102185882Histone H3; Belongs to the histone H3 family. (136 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (502 aa)
LOC108633554Histone domain-containing protein. (136 aa)
SFXN2Sideroflexin 2. (317 aa)
LOC102182848Histone H3; Belongs to the histone H3 family. (136 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
LOC108636012Histone H3; Belongs to the histone H3 family. (136 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (549 aa)
ALDH1L110-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (899 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108634231Histone H3; Belongs to the histone H3 family. (136 aa)
GLSGlutaminase. (673 aa)
PSPHPhosphoserine phosphatase. (225 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
TRIM27Tripartite motif containing 27. (513 aa)
AASSAminoadipate-semialdehyde synthase. (933 aa)
LOC102180554Histone H3; Belongs to the histone H3 family. (136 aa)
LOC106503499Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108633916Histone H3; Belongs to the histone H3 family. (136 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (586 aa)
LOC102171353Histone H3; Belongs to the histone H3 family. (136 aa)
LOC102169981Histone domain-containing protein. (136 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (618 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
TXNThioredoxin; Belongs to the thioredoxin family. (105 aa)
ASNSAsparagine synthetase [glutamine-hydrolyzing]. (561 aa)
ESRP1Epithelial splicing regulatory protein 1. (709 aa)
ATF4Activating transcription factor 4. (352 aa)
ESRRAEstrogen related receptor alpha. (422 aa)
SKP1S-phase kinase associated protein 1. (163 aa)
MTFMTMitochondrial methionyl-tRNA formyltransferase. (457 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
PXDNPeroxidasin. (1525 aa)
RPIARibose 5-phosphate isomerase A. (306 aa)
GSRGlutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (519 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
CTHCystathionine gamma-lyase. (415 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
EGFRReceptor protein-tyrosine kinase. (1208 aa)
MTHFD2Uncharacterized protein. (352 aa)
LOC102189503Histone H3; Belongs to the histone H3 family. (136 aa)
GLDCGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1020 aa)
SFXN1Sidoreflexin. (322 aa)
SLC25A38Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. (306 aa)
KDM4CLysine demethylase 4C. (1053 aa)
RYBPRING1 and YY1 binding protein. (228 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (655 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (274 aa)
SLC1A4Solute carrier family 1 member 4. (527 aa)
GCLMGlutamate-cysteine ligase modifier subunit. (274 aa)
BCAT1Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (398 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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