24 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EMC1	ER membrane protein complex subunit 1. (1035 aa)
	FZD4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (555 aa)
	SOX17	SRY-box transcription factor 17. (410 aa)
	AXIN2	Axin 2. (844 aa)
	CLDN5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1615 aa)
	RHO	Rhodopsin. (348 aa)
	FZD6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (714 aa)
	EMC10	ER membrane protein complex subunit 10. (262 aa)
	SLC2A1	MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (500 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	DKK1	Dickkopf WNT signaling pathway inhibitor 1. (262 aa)
	ACTB	Uncharacterized protein. (375 aa)
	GNRHR	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (328 aa)
	EMC3	ER membrane protein complex subunit 3; Belongs to the EMC3 family. (261 aa)
	TSPAN12	Tetraspanin. (305 aa)
	EMC2	ER membrane protein complex subunit 2. (329 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (295 aa)
	EMC6	ER membrane protein complex subunit 6. (110 aa)
	CD44	CD44 molecule (Indian blood group). (715 aa)
	CCN2	Cellular communication network factor 2. (349 aa)
	LEF1	HMG box domain-containing protein. (430 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	AXIN2	ENSCHIP00000011080	ENSCHIP00000022676	Uncharacterized protein.	Axin 2.	0.666
ACTB	CCN2	ENSCHIP00000011080	ENSCHIP00000030116	Uncharacterized protein.	Cellular communication network factor 2.	0.774
ACTB	CCND1	ENSCHIP00000011080	ENSCHIP00000006815	Uncharacterized protein.	Cyclin D1; Belongs to the cyclin family.	0.890
ACTB	CD44	ENSCHIP00000011080	ENSCHIP00000024231	Uncharacterized protein.	CD44 molecule (Indian blood group).	0.835
ACTB	CLDN5	ENSCHIP00000011080	ENSCHIP00000022107	Uncharacterized protein.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.775
ACTB	CTNNB1	ENSCHIP00000011080	ENSCHIP00000031016	Uncharacterized protein.	Catenin beta 1.	0.906
ACTB	DKK1	ENSCHIP00000011080	ENSCHIP00000013400	Uncharacterized protein.	Dickkopf WNT signaling pathway inhibitor 1.	0.625
ACTB	LEF1	ENSCHIP00000011080	ENSCHIP00000030629	Uncharacterized protein.	HMG box domain-containing protein.	0.657
ACTB	LRP5	ENSCHIP00000011080	ENSCHIP00000021146	Uncharacterized protein.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.620
ACTB	LRP6	ENSCHIP00000011080	ENSCHIP00000013402	Uncharacterized protein.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.662
ACTB	PDGFB	ENSCHIP00000011080	ENSCHIP00000031260	Uncharacterized protein.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.584
ACTB	RHO	ENSCHIP00000011080	ENSCHIP00000020505	Uncharacterized protein.	Rhodopsin.	0.665
ACTB	SLC2A1	ENSCHIP00000011080	ENSCHIP00000014557	Uncharacterized protein.	MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.618
ACTB	SOX17	ENSCHIP00000011080	ENSCHIP00000023300	Uncharacterized protein.	SRY-box transcription factor 17.	0.531
AXIN2	ACTB	ENSCHIP00000022676	ENSCHIP00000011080	Axin 2.	Uncharacterized protein.	0.666
AXIN2	CCND1	ENSCHIP00000022676	ENSCHIP00000006815	Axin 2.	Cyclin D1; Belongs to the cyclin family.	0.845
AXIN2	CD44	ENSCHIP00000022676	ENSCHIP00000024231	Axin 2.	CD44 molecule (Indian blood group).	0.656
AXIN2	CTNNB1	ENSCHIP00000022676	ENSCHIP00000031016	Axin 2.	Catenin beta 1.	0.998
AXIN2	DKK1	ENSCHIP00000022676	ENSCHIP00000013400	Axin 2.	Dickkopf WNT signaling pathway inhibitor 1.	0.901
AXIN2	FZD4	ENSCHIP00000022676	ENSCHIP00000032113	Axin 2.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.761