STRINGSTRING
ACTB ACTB ENSCHIP00000009386 ENSCHIP00000009386 LOC102169981 LOC102169981 LOC102171353 LOC102171353 LOC106503503 LOC106503503 LOC108636047 LOC108636047 LOC108633916 LOC108633916 LOC106503502 LOC106503502 BRCA1 BRCA1 TP53 TP53 PARP2 PARP2 LOC106503499 LOC106503499 NUBP2 NUBP2 LOC102189503 LOC102189503 LOC102180554 LOC102180554 LOC102172954 LOC102172954 FEN1 FEN1 LOC108634231 LOC108634231 H3-4 H3-4 LOC108636012 LOC108636012 LOC102182848 LOC102182848 LOC108633554 LOC108633554 LOC102180307 LOC102180307 LOC102185882 LOC102185882 LOC102191748 LOC102191748 XRCC1 XRCC1 ALB ALB PARP1 PARP1 POLA1 POLA1 PCNA PCNA PARG PARG CHD1L CHD1L NAMPT NAMPT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACTBUncharacterized protein. (375 aa)
ENSCHIP00000009386Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (102 aa)
LOC102169981Histone domain-containing protein. (136 aa)
LOC102171353Histone H3; Belongs to the histone H3 family. (136 aa)
LOC106503503Histone H4. (103 aa)
LOC108636047Histone H4. (103 aa)
LOC108633916Histone H3; Belongs to the histone H3 family. (136 aa)
LOC106503502Histone H4. (103 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1843 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
PARP2Poly [ADP-ribose] polymerase. (533 aa)
LOC106503499Histone H3; Belongs to the histone H3 family. (136 aa)
NUBP2Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (273 aa)
LOC102189503Histone H3; Belongs to the histone H3 family. (136 aa)
LOC102180554Histone H3; Belongs to the histone H3 family. (136 aa)
LOC102172954Histone H4. (103 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
LOC108634231Histone H3; Belongs to the histone H3 family. (136 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108636012Histone H3; Belongs to the histone H3 family. (136 aa)
LOC102182848Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108633554Histone domain-containing protein. (136 aa)
LOC102180307Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC102185882Histone H3; Belongs to the histone H3 family. (136 aa)
LOC102191748Histone domain-containing protein. (136 aa)
XRCC1X-ray repair cross complementing 1. (632 aa)
ALBSerum albumin. (608 aa)
PARP1Poly [ADP-ribose] polymerase. (1020 aa)
POLA1DNA polymerase. (1468 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
PARGPoly(ADP-ribose) glycohydrolase. (972 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (893 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (491 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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