STRINGSTRING
NANOG NANOG CSF1 CSF1 LOC102181148 LOC102181148 LOC102180290 LOC102180290 TLR2 TLR2 LOC102180168 LOC102180168 KITLG KITLG LOC108633351 LOC108633351 LOC102190650 LOC102190650 IL1B IL1B LOC102182683 LOC102182683 CCL2 CCL2 PAX6 PAX6 GAPDH GAPDH POU5F1 POU5F1 BMP4 BMP4 IL18 IL18 SOX17 SOX17 LOC102190919 LOC102190919 STAT3 STAT3 ALB ALB TLR4 TLR4 IRF3 IRF3 LOC102190507 LOC102190507 IL10 IL10 IFNG IFNG PXDN PXDN CD86 CD86 CD163 CD163 CXCL10 CXCL10 MSX1 MSX1 CASP1 CASP1 ACTB ACTB NCK1 NCK1 IL6R IL6R IL6 IL6 ALPL ALPL LOC102179897 LOC102179897 BCL10 BCL10 ENSCHIP00000007600 ENSCHIP00000007600 CD4 CD4 NCK2 NCK2 LOC102190876 LOC102190876 CD80 CD80 ZNF7 ZNF7 TNF TNF AFP AFP CD40LG CD40LG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NANOGHomeobox domain-containing protein. (300 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
LOC102181148Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
LOC102180290USP domain-containing protein; Belongs to the peptidase C19 family. (349 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (794 aa)
LOC102180168Uncharacterized protein; Belongs to the alkaline phosphatase family. (531 aa)
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (274 aa)
LOC108633351Uncharacterized protein; Belongs to the alkaline phosphatase family. (531 aa)
LOC102190650Uncharacterized protein; Belongs to the alkaline phosphatase family. (528 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
LOC102182683C-X-C motif chemokine. (109 aa)
CCL2C-C motif chemokine. (98 aa)
PAX6Paired box 6. (486 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
POU5F1POU domain protein. (360 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
SOX17SRY-box transcription factor 17. (410 aa)
LOC102190919Alkaline phosphatase. (530 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
ALBSerum albumin. (608 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
IRF3Interferon regulatory factor 3. (418 aa)
LOC102190507Uncharacterized protein. (139 aa)
IL10Interleukin 10. (177 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
PXDNPeroxidasin. (1525 aa)
CD86Ig-like domain-containing protein. (289 aa)
CD163CD163 molecule. (1114 aa)
CXCL10C-X-C motif chemokine. (102 aa)
MSX1Msh homeobox 1. (303 aa)
CASP1Uncharacterized protein; Belongs to the peptidase C14A family. (411 aa)
ACTBUncharacterized protein. (375 aa)
NCK1Cytoplasmic protein. (377 aa)
IL6RInterleukin 6 receptor. (441 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
ALPLAlkaline phosphatase. (524 aa)
LOC102179897Alkaline phosphatase. (530 aa)
BCL10BCL10 immune signaling adaptor. (230 aa)
ENSCHIP00000007600Uncharacterized protein. (352 aa)
CD4CD4 molecule. (455 aa)
NCK2Cytoplasmic protein. (376 aa)
LOC102190876Alkaline phosphatase. (530 aa)
CD80CD80 molecule. (302 aa)
ZNF7Zinc finger protein 7. (675 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
AFPAlpha fetoprotein. (610 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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