STRINGSTRING
MMP2 MMP2 FASLG FASLG FOSB FOSB TNFSF9 TNFSF9 PDGFRA PDGFRA ADAMTS1 ADAMTS1 JARID2 JARID2 POSTN POSTN CD4 CD4 GPRC5A GPRC5A GREM1 GREM1 DKK3 DKK3 FGF18 FGF18 ADAM12 ADAM12 LGALS3 LGALS3 SMOC1 SMOC1 CDK6 CDK6 TWIST1 TWIST1 COL11A1 COL11A1 COL5A2 COL5A2 TNFRSF1A TNFRSF1A BMP2 BMP2 TNFAIP6 TNFAIP6 CD74 CD74 LOC102190927 LOC102190927 LGALS1 LGALS1 ATF4 ATF4 ADAMTS14 ADAMTS14 CD99 CD99 DAG1 DAG1 RUNX2 RUNX2 PXDN PXDN OGN OGN IHH IHH THBS2 THBS2 SLC7A1 SLC7A1 SEMA4C SEMA4C BTG2 BTG2 THBS1 THBS1 FAT1 FAT1 FGF2 FGF2 COL6A3 COL6A3 ADAMTS5 ADAMTS5 COL12A1 COL12A1 ARID5B ARID5B EFNB2 EFNB2 ADAMTS12 ADAMTS12 SCRG1 SCRG1 SORL1 SORL1 MDK MDK ACAN ACAN MMP13 MMP13 DPP4 DPP4 NOTCH1 NOTCH1 COL1A1 COL1A1 CD44 CD44 IBSP IBSP PROCR PROCR CST7 CST7 COL4A1 COL4A1 PLA2G2A PLA2G2A ENAH ENAH PTPRC PTPRC PGRMC2 PGRMC2 MMP3 MMP3 HBEGF HBEGF COL14A1 COL14A1 CCL2 CCL2 THY1 THY1 IL1B IL1B ATP2B1 ATP2B1 TNFRSF11B TNFRSF11B ENPP1 ENPP1 ZFP36L2 ZFP36L2 FOS FOS BGLAP BGLAP COL4A2 COL4A2 COL15A1 COL15A1 LOC102180880 LOC102180880 FAM3C FAM3C FGF1 FGF1 CSF1 CSF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MMP2Matrix metallopeptidase 2. (661 aa)
FASLGFasL; Belongs to the tumor necrosis factor family. (277 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (341 aa)
TNFSF9TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (252 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1108 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (971 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1258 aa)
POSTNPeriostin. (836 aa)
CD4CD4 molecule. (455 aa)
GPRC5AG protein-coupled receptor class C group 5 member A. (357 aa)
GREM1Gremlin. (184 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (349 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ADAM12ADAM metallopeptidase domain 12. (903 aa)
LGALS3Galectin. (260 aa)
SMOC1SPARC related modular calcium binding 1. (435 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
TWIST1BHLH domain-containing protein. (163 aa)
COL11A1Collagen type XI alpha 1 chain. (1323 aa)
COL5A2Collagen type V alpha 2 chain. (1252 aa)
TNFRSF1ATNF receptor superfamily member 1A. (449 aa)
BMP2TGF_BETA_2 domain-containing protein. (381 aa)
TNFAIP6TNF alpha induced protein 6. (280 aa)
CD74CD74 molecule. (261 aa)
LOC102190927Ig-like domain-containing protein. (299 aa)
LGALS1Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Has hemaglutinating activity towards human erythrocytes. (136 aa)
ATF4Activating transcription factor 4. (352 aa)
ADAMTS14ADAM metallopeptidase with thrombospondin type 1 motif 14. (1219 aa)
CD99Uncharacterized protein. (238 aa)
DAG1Dystroglycan 1. (895 aa)
RUNX2RUNX family transcription factor 2. (585 aa)
PXDNPeroxidasin. (1525 aa)
OGNUncharacterized protein. (299 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
THBS2Thrombospondin 2. (1181 aa)
SLC7A1Solute carrier family 7 member 1. (629 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
BTG2BTG anti-proliferation factor 2. (164 aa)
THBS1Thrombospondin 1. (1218 aa)
FAT1FAT atypical cadherin 1. (4643 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
COL6A3Collagen type VI alpha 3 chain. (3111 aa)
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif 5. (934 aa)
COL12A1Collagen type XII alpha 1 chain. (3046 aa)
ARID5BAT-rich interaction domain 5B. (1187 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (335 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1605 aa)
SCRG1Stimulator of chondrogenesis 1. (98 aa)
SORL1Sortilin related receptor 1. (2211 aa)
MDKMidkine. (143 aa)
ACANAggrecan. (2402 aa)
MMP13Matrix metallopeptidase 13. (472 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (767 aa)
NOTCH1Notch receptor 1. (2508 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
CD44CD44 molecule (Indian blood group). (715 aa)
IBSPIntegrin binding sialoprotein. (306 aa)
PROCRProtein C receptor. (241 aa)
CST7Cystatin F. (134 aa)
COL4A1Collagen type IV alpha 1 chain. (1608 aa)
PLA2G2APhospholipase A(2). (144 aa)
ENAHENAH actin regulator. (800 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1067 aa)
PGRMC2Progesterone receptor membrane component 2; Belongs to the cytochrome b5 family. (247 aa)
MMP3Matrix metallopeptidase 3. (477 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
COL14A1Collagen type XIV alpha 1 chain. (1775 aa)
CCL2C-C motif chemokine. (98 aa)
THY1Thy-1 cell surface antigen. (161 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1245 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (402 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (818 aa)
ZFP36L2ZFP36 ring finger protein like 2. (490 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (97 aa)
COL4A2Collagen type IV alpha 2 chain. (1607 aa)
COL15A1Collagen type XV alpha 1 chain. (1375 aa)
LOC102180880C-C motif chemokine. (92 aa)
FAM3CFamily with sequence similarity 3 member C. (227 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (554 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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