STRINGSTRING
SPRED2 SPRED2 CUL4A CUL4A FOSB FOSB JUN JUN H2AC21 H2AC21 MYL6B MYL6B JUNB JUNB ARPC2 ARPC2 CUL3 CUL3 NEDD8 NEDD8 SUMO1 SUMO1 SMC6 SMC6 FOSL2 FOSL2 SUMO4 SUMO4 SETDB1 SETDB1 MYH11 MYH11 LOC102168811 LOC102168811 DUSP4 DUSP4 ATF2 ATF2 THAP11 THAP11 KIF5C KIF5C H2AX H2AX PER1 PER1 SUN1 SUN1 ACTB ACTB LMNB1 LMNB1 DAXX DAXX PRMT1 PRMT1 KIF5A KIF5A KLC2 KLC2 ACTR3 ACTR3 PRMT8 PRMT8 SUMO3 SUMO3 GADD45G GADD45G PRMT5 PRMT5 LOX LOX MYH6 MYH6 SMC5 SMC5 EZR EZR LOC102183306 LOC102183306 MYH10 MYH10 RRP8 RRP8 KIF5B KIF5B MYH9 MYH9 NSMCE1 NSMCE1 TPM1 TPM1 MYO5A MYO5A MYL9 MYL9 SPHK1 SPHK1 CUL4B CUL4B DUSP1 DUSP1 CORO1C CORO1C GAPDH GAPDH TINF2 TINF2 NACC1 NACC1 ARPC3 ARPC3 FOS FOS GADD45A GADD45A CEBPB CEBPB SUMO2 SUMO2 ACTG1 ACTG1 NSMCE2 NSMCE2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPRED2Sprouty related EVH1 domain containing 2. (415 aa)
CUL4ACullin 4A; Belongs to the cullin family. (764 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (341 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (335 aa)
H2AC21Histone H2A; Belongs to the histone H2A family. (130 aa)
MYL6BMyosin light chain 6B. (211 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (303 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
NEDD8NEDD8 ubiquitin like modifier. (77 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
SMC6Structural maintenance of chromosomes 6. (1116 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (327 aa)
SUMO4Small ubiquitin-related modifier. (95 aa)
SETDB1SET domain bifurcated histone lysine methyltransferase 1. (1287 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1972 aa)
LOC102168811Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (289 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
THAP11THAP domain containing 11. (303 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (957 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
PER1Period circadian regulator 1. (1289 aa)
SUN1Sad1 and UNC84 domain containing 1. (889 aa)
ACTBUncharacterized protein. (375 aa)
LMNB1Lamin B1; Belongs to the intermediate filament family. (586 aa)
DAXXDaxx domain-containing protein. (737 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
KIF5AKinesin family member 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1063 aa)
KLC2Kinesin light chain 2. (622 aa)
ACTR3Uncharacterized protein; Belongs to the actin family. (405 aa)
PRMT8Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (444 aa)
SUMO3Small ubiquitin-related modifier. (104 aa)
GADD45GGrowth arrest and DNA damage inducible gamma. (159 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa)
LOXLysyl oxidase. (418 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1943 aa)
SMC5AAA_23 domain-containing protein. (1104 aa)
EZREzrin. (581 aa)
LOC102183306Histone H2A; Belongs to the histone H2A family. (128 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1975 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (487 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1986 aa)
NSMCE1NSE1 homolog, SMC5-SMC6 complex component. (266 aa)
TPM1Uncharacterized protein; Belongs to the tropomyosin family. (284 aa)
MYO5AMyosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1896 aa)
MYL9Myosin light chain 9. (172 aa)
SPHK1Sphingosine kinase 1. (392 aa)
CUL4BCullin 4B; Belongs to the cullin family. (1027 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
TINF2TERF1 interacting nuclear factor 2. (458 aa)
NACC1Nucleus accumbens associated 1. (535 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (194 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CEBPBCCAAT/enhancer-binding protein. (307 aa)
SUMO2Small ubiquitin-related modifier. (95 aa)
ACTG1Actin gamma 1. (376 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (277 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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