50 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TFRC	Transferrin receptor. (790 aa)
	PYCR1	Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (320 aa)
	CDCA7	Cell division cycle associated 7. (450 aa)
	BCL6	BCL6 transcription repressor. (706 aa)
	CCR6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	SLC1A4	Solute carrier family 1 member 4. (527 aa)
	BCAT1	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (398 aa)
	RUNX3	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (435 aa)
	BHLHE41	Basic helix-loop-helix family member e41. (487 aa)
	IARS1	Isoleucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1262 aa)
	SESN2	Sestrin 2. (471 aa)
	PSAT1	Phosphoserine aminotransferase. (370 aa)
	CD19	CD19 molecule. (561 aa)
	PRDM1	PR/SET domain 1. (851 aa)
	DNMT1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1591 aa)
	KLF3	Kruppel-like factor 3. (345 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	CD27	CD27 molecule. (270 aa)
	MTHFD2	Uncharacterized protein. (352 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1130 aa)
	SLC7A5	Solute carrier family 7 member 5. (505 aa)
	HELLS	Helicase, lymphoid specific. (824 aa)
	NARS1	Asparaginyl-tRNA synthetase. (559 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa)
	LOC102168547	Beta-2-microglobulin. (124 aa)
	UHRF1	Ubiquitin like with PHD and ring finger domains 1. (786 aa)
	TEX13B	RanBP2-type domain-containing protein. (348 aa)
	PHGDH	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
	CHAC1	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (260 aa)
	IRF4	Interferon regulatory factor 4. (450 aa)
	CD24	Uncharacterized protein. (78 aa)
	BHLHE40	Basic helix-loop-helix family member e40. (412 aa)
	YARS1	Tyrosine--tRNA ligase. (528 aa)
	DNMT3A	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (915 aa)
	LYNX1	Ly6/neurotoxin 1. (116 aa)
	ASNS	Asparagine synthetase [glutamine-hydrolyzing]. (561 aa)
	LOC102186027	BHLH domain-containing protein. (411 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (275 aa)
	CD93	CD93 molecule. (649 aa)
	PSPH	Phosphoserine phosphatase. (225 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (124 aa)
	ENSCHIP00000004646	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
	KLF2	Kruppel like factor 2. (361 aa)
	S1PR1	Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
	HHEX	Hematopoietically expressed homeobox. (271 aa)
	ZBTB32	Zinc finger and BTB domain containing 32. (490 aa)
	CD38	Uncharacterized protein. (277 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (502 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (129 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASNS	BCAT1	ENSCHIP00000012001	ENSCHIP00000030336	Asparagine synthetase [glutamine-hydrolyzing].	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.459
ASNS	CHAC1	ENSCHIP00000012001	ENSCHIP00000017771	Asparagine synthetase [glutamine-hydrolyzing].	Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.	0.868
ASNS	IARS1	ENSCHIP00000012001	ENSCHIP00000028065	Asparagine synthetase [glutamine-hydrolyzing].	Isoleucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.549
ASNS	MTHFD2	ENSCHIP00000012001	ENSCHIP00000024076	Asparagine synthetase [glutamine-hydrolyzing].	Uncharacterized protein.	0.775
ASNS	NARS1	ENSCHIP00000012001	ENSCHIP00000020781	Asparagine synthetase [glutamine-hydrolyzing].	Asparaginyl-tRNA synthetase.	0.666
ASNS	PHGDH	ENSCHIP00000012001	ENSCHIP00000019405	Asparagine synthetase [glutamine-hydrolyzing].	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.818
ASNS	PSAT1	ENSCHIP00000012001	ENSCHIP00000027621	Asparagine synthetase [glutamine-hydrolyzing].	Phosphoserine aminotransferase.	0.831
ASNS	PSPH	ENSCHIP00000012001	ENSCHIP00000004779	Asparagine synthetase [glutamine-hydrolyzing].	Phosphoserine phosphatase.	0.630
ASNS	SHMT2	ENSCHIP00000012001	ENSCHIP00000001693	Asparagine synthetase [glutamine-hydrolyzing].	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.806
ASNS	SLC1A4	ENSCHIP00000012001	ENSCHIP00000030667	Asparagine synthetase [glutamine-hydrolyzing].	Solute carrier family 1 member 4.	0.486
ASNS	SLC7A5	ENSCHIP00000012001	ENSCHIP00000021590	Asparagine synthetase [glutamine-hydrolyzing].	Solute carrier family 7 member 5.	0.639
ASNS	YARS1	ENSCHIP00000012001	ENSCHIP00000012684	Asparagine synthetase [glutamine-hydrolyzing].	Tyrosine--tRNA ligase.	0.412
B2M	CASP3	ENSCHIP00000004681	ENSCHIP00000011490	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Caspase 3; Belongs to the peptidase C14A family.	0.471
B2M	CD19	ENSCHIP00000004681	ENSCHIP00000027580	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	CD19 molecule.	0.583
B2M	ENSCHIP00000004646	ENSCHIP00000004681	ENSCHIP00000004646	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.545
B2M	GAPDH	ENSCHIP00000004681	ENSCHIP00000025974	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Glyceraldehyde-3-phosphate dehydrogenase.	0.871
B2M	IL4	ENSCHIP00000004681	ENSCHIP00000020527	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.552
B2M	LOC102168547	ENSCHIP00000004681	ENSCHIP00000020182	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Beta-2-microglobulin.	0.543
B2M	TFRC	ENSCHIP00000004681	ENSCHIP00000033446	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Transferrin receptor.	0.703
BCAT1	ASNS	ENSCHIP00000030336	ENSCHIP00000012001	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Asparagine synthetase [glutamine-hydrolyzing].	0.459