(10 nodes) (2023) Genome editing of patient-derived iPSCs identifies a deep intronic variant causing aberrant splicing in hemophilia A. network (Capra hircus)

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Your Input:
	THPO	Thrombopoietin. (353 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	KITLG	Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (274 aa)
	ENSCHIP00000003677	Tr-type G domain-containing protein. (438 aa)
	LOC108636537	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (441 aa)
	EEF1A1	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (462 aa)
	CEP290	Centrosomal protein 290. (2470 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
	EEF1A2	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (463 aa)
	ENSCHIP00000016659	Tr-type G domain-containing protein. (120 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EEF1A1	GAPDH	ENSCHIP00000006227	ENSCHIP00000025974	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	Glyceraldehyde-3-phosphate dehydrogenase.	0.741
EEF1A2	GAPDH	ENSCHIP00000016275	ENSCHIP00000025974	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	Glyceraldehyde-3-phosphate dehydrogenase.	0.644
ENSCHIP00000003677	GAPDH	ENSCHIP00000003677	ENSCHIP00000025974	Tr-type G domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.614
ENSCHIP00000016659	GAPDH	ENSCHIP00000016659	ENSCHIP00000025974	Tr-type G domain-containing protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.613
GAPDH	EEF1A1	ENSCHIP00000025974	ENSCHIP00000006227	Glyceraldehyde-3-phosphate dehydrogenase.	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	0.741
GAPDH	EEF1A2	ENSCHIP00000025974	ENSCHIP00000016275	Glyceraldehyde-3-phosphate dehydrogenase.	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	0.644
GAPDH	ENSCHIP00000003677	ENSCHIP00000025974	ENSCHIP00000003677	Glyceraldehyde-3-phosphate dehydrogenase.	Tr-type G domain-containing protein.	0.614
GAPDH	ENSCHIP00000016659	ENSCHIP00000025974	ENSCHIP00000016659	Glyceraldehyde-3-phosphate dehydrogenase.	Tr-type G domain-containing protein.	0.613
GAPDH	IL6	ENSCHIP00000025974	ENSCHIP00000009414	Glyceraldehyde-3-phosphate dehydrogenase.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.940
GAPDH	KITLG	ENSCHIP00000025974	ENSCHIP00000030559	Glyceraldehyde-3-phosphate dehydrogenase.	Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family.	0.664
GAPDH	LOC108636537	ENSCHIP00000025974	ENSCHIP00000003897	Glyceraldehyde-3-phosphate dehydrogenase.	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	0.614
IL6	GAPDH	ENSCHIP00000009414	ENSCHIP00000025974	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Glyceraldehyde-3-phosphate dehydrogenase.	0.940
IL6	KITLG	ENSCHIP00000009414	ENSCHIP00000030559	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family.	0.885
IL6	THPO	ENSCHIP00000009414	ENSCHIP00000018239	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	Thrombopoietin.	0.722
KITLG	GAPDH	ENSCHIP00000030559	ENSCHIP00000025974	Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.664
KITLG	IL6	ENSCHIP00000030559	ENSCHIP00000009414	Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.885
KITLG	THPO	ENSCHIP00000030559	ENSCHIP00000018239	Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family.	Thrombopoietin.	0.921
LOC108636537	GAPDH	ENSCHIP00000003897	ENSCHIP00000025974	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	Glyceraldehyde-3-phosphate dehydrogenase.	0.614
THPO	IL6	ENSCHIP00000018239	ENSCHIP00000009414	Thrombopoietin.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.722
THPO	KITLG	ENSCHIP00000018239	ENSCHIP00000030559	Thrombopoietin.	Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family.	0.921