STRINGSTRING
RET RET KIT KIT GOT1 GOT1 TP53 TP53 RIPK1 RIPK1 GSDME GSDME SRC SRC FLT3 FLT3 GSDMD GSDMD GOT2 GOT2 CASP1 CASP1 CASP3 CASP3 YBX1 YBX1 DHFR DHFR RIPK3 RIPK3 LDH-A LDH-A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1118 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (974 aa)
GOT1Aspartate aminotransferase. (413 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (667 aa)
GSDMEGasdermin E. (495 aa)
SRCTyrosine-protein kinase. (538 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (992 aa)
GSDMDGasdermin D. (483 aa)
GOT2Aspartate aminotransferase. (430 aa)
CASP1Uncharacterized protein; Belongs to the peptidase C14A family. (411 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (275 aa)
YBX1CSD_1 domain-containing protein. (324 aa)
DHFRDHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa)
RIPK3Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (243 aa)
LDH-AL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (361 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
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