38 items (Capra hircus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
	COL5A3	Collagen type V alpha 3 chain. (1455 aa)
	CDKN2B	Cyclin dependent kinase inhibitor 2B. (138 aa)
	COL4A2	Collagen type IV alpha 2 chain. (1607 aa)
	MMP12	Matrix metallopeptidase 12. (470 aa)
	MMP8	Matrix metallopeptidase 8. (470 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (161 aa)
	CDK2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa)
	TIMP1	NTR domain-containing protein. (207 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (732 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	CDKN1C	Cyclin dependent kinase inhibitor 1C. (254 aa)
	ACTB	Uncharacterized protein. (375 aa)
	SIRT3	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (333 aa)
	LOXL2	Lysyl oxidase like 2. (791 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (198 aa)
	C5AR1	Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
	LOX	Lysyl oxidase. (418 aa)
	ELN	Uncharacterized protein. (504 aa)
	CDKN2C	Cyclin dependent kinase inhibitor 2C. (168 aa)
	ALB	Serum albumin. (608 aa)
	CDKN2D	Cyclin dependent kinase inhibitor 2D. (166 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	VIM	Vimentin; Belongs to the intermediate filament family. (471 aa)
	CDK4	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (402 aa)
	MMP13	Matrix metallopeptidase 13. (472 aa)
	COL1A1	Collagen type I alpha 1 chain. (1463 aa)
	LOXL1	Lysyl oxidase like 1. (592 aa)
	COL4A1	Collagen type IV alpha 1 chain. (1608 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
	MMP3	Matrix metallopeptidase 3. (477 aa)
	COL14A1	Collagen type XIV alpha 1 chain. (1775 aa)
	LOXL4	Lysyl oxidase like 4. (757 aa)
	COL16A1	Collagen type XVI alpha 1 chain. (1414 aa)
	C1QA	Complement C1q A chain. (313 aa)
	COL1A2	Collagen type I alpha 2 chain. (1128 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	CDK2	ENSCHIP00000011080	ENSCHIP00000003142	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.838
ACTB	CDK4	ENSCHIP00000011080	ENSCHIP00000022710	Uncharacterized protein.	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	0.824
ACTB	CDKN1A	ENSCHIP00000011080	ENSCHIP00000002564	Uncharacterized protein.	Cyclin dependent kinase inhibitor 1A.	0.640
ACTB	CDKN1B	ENSCHIP00000011080	ENSCHIP00000015316	Uncharacterized protein.	Cyclin dependent kinase inhibitor 1B.	0.471
ACTB	COL1A1	ENSCHIP00000011080	ENSCHIP00000023918	Uncharacterized protein.	Collagen type I alpha 1 chain.	0.776
ACTB	COL1A2	ENSCHIP00000011080	ENSCHIP00000031191	Uncharacterized protein.	Collagen type I alpha 2 chain.	0.563
ACTB	ELN	ENSCHIP00000011080	ENSCHIP00000018772	Uncharacterized protein.	Uncharacterized protein.	0.519
ACTB	LOX	ENSCHIP00000011080	ENSCHIP00000017017	Uncharacterized protein.	Lysyl oxidase.	0.693
ACTB	MMP12	ENSCHIP00000011080	ENSCHIP00000032834	Uncharacterized protein.	Matrix metallopeptidase 12.	0.441
ACTB	MMP13	ENSCHIP00000011080	ENSCHIP00000023527	Uncharacterized protein.	Matrix metallopeptidase 13.	0.722
ACTB	MMP3	ENSCHIP00000011080	ENSCHIP00000026267	Uncharacterized protein.	Matrix metallopeptidase 3.	0.755
ACTB	SERPINE1	ENSCHIP00000011080	ENSCHIP00000023172	Uncharacterized protein.	Serpin family E member 1; Belongs to the serpin family.	0.634
ACTB	SIRT1	ENSCHIP00000011080	ENSCHIP00000007571	Uncharacterized protein.	Deacetylase sirtuin-type domain-containing protein.	0.852
ACTB	SIRT3	ENSCHIP00000011080	ENSCHIP00000014223	Uncharacterized protein.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.670
ACTB	SMAD2	ENSCHIP00000011080	ENSCHIP00000022106	Uncharacterized protein.	Mothers against decapentaplegic homolog.	0.849
ACTB	TGFB1	ENSCHIP00000011080	ENSCHIP00000008885	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.831
ACTB	TGFBR1	ENSCHIP00000011080	ENSCHIP00000025782	Uncharacterized protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.610
ACTB	TGFBR2	ENSCHIP00000011080	ENSCHIP00000008226	Uncharacterized protein.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.615
ACTB	TIMP1	ENSCHIP00000011080	ENSCHIP00000006216	Uncharacterized protein.	NTR domain-containing protein.	0.567