(48 nodes) (2024) Fibrinogen in mice cerebral microvessels induces blood-brain barrier dysregulation with aging via a dynamin-related protein 1-dependent pathway. network (Capra hircus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (402 aa)
	CSTF1	Cleavage stimulation factor subunit 1. (431 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
	THY1	Thy-1 cell surface antigen. (161 aa)
	PPP2CA	Serine/threonine-protein phosphatase. (309 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	FIS1	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
	MYL9	Myosin light chain 9. (172 aa)
	CLDN5	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
	MYH9	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1986 aa)
	NECTIN3	Nectin cell adhesion molecule 3. (549 aa)
	PECAM1	Platelet and endothelial cell adhesion molecule 1. (739 aa)
	ALB	Serum albumin. (608 aa)
	MYH10	Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1975 aa)
	FGA	Fibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it [...] (618 aa)
	MMP9	Uncharacterized protein. (709 aa)
	STX1B	Syntaxin 1B; Belongs to the syntaxin family. (288 aa)
	CSTF3	Cleavage stimulation factor subunit 3. (692 aa)
	MFN2	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
	ICAM1	Intercellular adhesion molecule 1. (532 aa)
	CPSF1	Cleavage and polyadenylation specific factor 1. (1415 aa)
	MYLK	Myosin light chain kinase. (1887 aa)
	GPAA1	Glycosylphosphatidylinositol anchor attachment 1. (617 aa)
	FGB	Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (494 aa)
	FGG	Fibrinogen gamma chain. (442 aa)
	CPSF4	Cleavage and polyadenylation specific factor 4. (269 aa)
	RHOA	Ras-like protein family member A. (193 aa)
	SPTAN1	Spectrin alpha chain, non-erythrocytic 1. (2452 aa)
	ACTB	Uncharacterized protein. (375 aa)
	VAMP3	Vesicle associated membrane protein 3. (104 aa)
	SNCA	Alpha-synuclein; Belongs to the synuclein family. (140 aa)
	MYO18A	Myosin XVIIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2049 aa)
	PRKAR1A	Protein kinase cAMP-dependent type I regulatory subunit alpha. (380 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (550 aa)
	CLDN11	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (207 aa)
	PPP2R2A	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (466 aa)
	MYL6B	Myosin light chain 6B. (211 aa)
	FGA-2	Fibrinogen C-terminal domain-containing protein. (206 aa)
	CTNNA1	Catenin alpha 1. (1018 aa)
	ACTC1	Actin alpha cardiac muscle 1. (377 aa)
	PPM1L	Protein phosphatase, Mg2+/Mn2+ dependent 1L. (233 aa)
	OCLN	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)
	VAPA	VAMP associated protein A. (294 aa)
	PLAT	Plasminogen activator; Belongs to the peptidase S1 family. (565 aa)
	NECTIN1	Nectin cell adhesion molecule 1. (515 aa)
	MAPT	Microtubule-associated protein. (744 aa)
	PRKAR2B	Protein kinase cAMP-dependent type II regulatory subunit beta. (417 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	AKT1	ENSCHIP00000011080	ENSCHIP00000027335	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.755
ACTB	ALB	ENSCHIP00000011080	ENSCHIP00000020234	Uncharacterized protein.	Serum albumin.	0.961
ACTB	CLDN5	ENSCHIP00000011080	ENSCHIP00000022107	Uncharacterized protein.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.775
ACTB	CTNNA1	ENSCHIP00000011080	ENSCHIP00000002514	Uncharacterized protein.	Catenin alpha 1.	0.945
ACTB	FIS1	ENSCHIP00000011080	ENSCHIP00000025830	Uncharacterized protein.	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.	0.693
ACTB	GAPDH	ENSCHIP00000011080	ENSCHIP00000025974	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.979
ACTB	ICAM1	ENSCHIP00000011080	ENSCHIP00000015201	Uncharacterized protein.	Intercellular adhesion molecule 1.	0.813
ACTB	MAPT	ENSCHIP00000011080	ENSCHIP00000032228	Uncharacterized protein.	Microtubule-associated protein.	0.563
ACTB	MFN2	ENSCHIP00000011080	ENSCHIP00000015994	Uncharacterized protein.	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.786
ACTB	MMP9	ENSCHIP00000011080	ENSCHIP00000016938	Uncharacterized protein.	Uncharacterized protein.	0.881
ACTB	MYH10	ENSCHIP00000011080	ENSCHIP00000019825	Uncharacterized protein.	Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.952
ACTB	MYH9	ENSCHIP00000011080	ENSCHIP00000021370	Uncharacterized protein.	Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.964
ACTB	MYL6B	ENSCHIP00000011080	ENSCHIP00000002873	Uncharacterized protein.	Myosin light chain 6B.	0.944
ACTB	MYL9	ENSCHIP00000011080	ENSCHIP00000023463	Uncharacterized protein.	Myosin light chain 9.	0.947
ACTB	OCLN	ENSCHIP00000011080	ENSCHIP00000001094	Uncharacterized protein.	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family.	0.856
ACTB	PECAM1	ENSCHIP00000011080	ENSCHIP00000020243	Uncharacterized protein.	Platelet and endothelial cell adhesion molecule 1.	0.740
ACTB	PLAT	ENSCHIP00000011080	ENSCHIP00000000197	Uncharacterized protein.	Plasminogen activator; Belongs to the peptidase S1 family.	0.684
ACTB	PPP2CA	ENSCHIP00000011080	ENSCHIP00000027969	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.417
ACTB	PRKACB	ENSCHIP00000011080	ENSCHIP00000029151	Uncharacterized protein.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.776
ACTB	PTEN	ENSCHIP00000011080	ENSCHIP00000002897	Uncharacterized protein.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.844