(12 nodes) (2023) Intranasal immunisation with recombinant Toxoplasma gondii uridine phosphorylase confers resistance against acute toxoplasmosis in mice. network (Capra hircus)

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	RACK1	Receptor for activated C kinase 1. (317 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family. (166 aa)
	UPRT	Uracil phosphoribosyltransferase homolog. (306 aa)
	IL10	Interleukin 10. (177 aa)
	UPP2	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (330 aa)
	IDO1	Uncharacterized protein. (410 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. (155 aa)
	IDO2	Indoleamine 2,3-dioxygenase 2. (407 aa)
	CDA	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa)
	PGAM2	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
	CD4	CD4 molecule. (455 aa)
	UPP1	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (312 aa)

Your Current Organism:

Capra hircus

NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	CDA	ENSCHIP00000006662	ENSCHIP00000033674	CD4 molecule.	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.445
CD4	IDO1	ENSCHIP00000006662	ENSCHIP00000021645	CD4 molecule.	Uncharacterized protein.	0.907
CD4	IDO2	ENSCHIP00000006662	ENSCHIP00000030433	CD4 molecule.	Indoleamine 2,3-dioxygenase 2.	0.850
CD4	IFNG	ENSCHIP00000006662	ENSCHIP00000016152	CD4 molecule.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.992
CD4	IL10	ENSCHIP00000006662	ENSCHIP00000016929	CD4 molecule.	Interleukin 10.	0.995
CD4	IL2	ENSCHIP00000006662	ENSCHIP00000029633	CD4 molecule.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family.	0.995
CDA	CD4	ENSCHIP00000033674	ENSCHIP00000006662	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	CD4 molecule.	0.445
CDA	UPP1	ENSCHIP00000033674	ENSCHIP00000013138	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.	0.995
CDA	UPP2	ENSCHIP00000033674	ENSCHIP00000018437	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.	0.994
CDA	UPRT	ENSCHIP00000033674	ENSCHIP00000016505	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Uracil phosphoribosyltransferase homolog.	0.562
IDO1	CD4	ENSCHIP00000021645	ENSCHIP00000006662	Uncharacterized protein.	CD4 molecule.	0.907
IDO1	IDO2	ENSCHIP00000021645	ENSCHIP00000030433	Uncharacterized protein.	Indoleamine 2,3-dioxygenase 2.	0.908
IDO1	IFNG	ENSCHIP00000021645	ENSCHIP00000016152	Uncharacterized protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.856
IDO1	IL10	ENSCHIP00000021645	ENSCHIP00000016929	Uncharacterized protein.	Interleukin 10.	0.830
IDO1	IL2	ENSCHIP00000021645	ENSCHIP00000029633	Uncharacterized protein.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family.	0.627
IDO2	CD4	ENSCHIP00000030433	ENSCHIP00000006662	Indoleamine 2,3-dioxygenase 2.	CD4 molecule.	0.850
IDO2	IDO1	ENSCHIP00000030433	ENSCHIP00000021645	Indoleamine 2,3-dioxygenase 2.	Uncharacterized protein.	0.908
IDO2	IFNG	ENSCHIP00000030433	ENSCHIP00000016152	Indoleamine 2,3-dioxygenase 2.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity); Belongs to the type II (or gamma) interferon family.	0.880
IDO2	IL10	ENSCHIP00000030433	ENSCHIP00000016929	Indoleamine 2,3-dioxygenase 2.	Interleukin 10.	0.873
IDO2	IL2	ENSCHIP00000030433	ENSCHIP00000029633	Indoleamine 2,3-dioxygenase 2.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family.	0.593