STRINGSTRING
SPEN SPEN TP53 TP53 NPPA NPPA IL1B IL1B GLB1L3 GLB1L3 COL14A1 COL14A1 COL8A2 COL8A2 COL16A1 COL16A1 COL1A2 COL1A2 COL4A6 COL4A6 SLC39A8 SLC39A8 IL1A IL1A TGFB1 TGFB1 IL6 IL6 COL11A1 COL11A1 COL5A2 COL5A2 ACTA1 ACTA1 TSG101 TSG101 NDUFB7 NDUFB7 GLB1 GLB1 TAGLN TAGLN PPARGC1A PPARGC1A TTN TTN MYH6 MYH6 ALB ALB COL12A1 COL12A1 MTOR MTOR TNNI3 TNNI3 COL24A1 COL24A1 TNNT2 TNNT2 IL18 IL18 MMP13 MMP13 COL1A1 COL1A1 FBN1 FBN1 MYH7 MYH7 LOC108633295 LOC108633295 PLA2G2A PLA2G2A KIT KIT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPENSpen family transcriptional repressor. (3654 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (382 aa)
NPPANatriuretic peptide A. (188 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
GLB1L3Beta-galactosidase. (664 aa)
COL14A1Collagen type XIV alpha 1 chain. (1775 aa)
COL8A2Collagen type VIII alpha 2 chain. (704 aa)
COL16A1Collagen type XVI alpha 1 chain. (1414 aa)
COL1A2Collagen type I alpha 2 chain. (1128 aa)
COL4A6Collagen IV NC1 domain-containing protein. (170 aa)
SLC39A8Solute carrier family 39 member 8. (461 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (254 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (237 aa)
COL11A1Collagen type XI alpha 1 chain. (1323 aa)
COL5A2Collagen type V alpha 2 chain. (1252 aa)
ACTA1Uncharacterized protein; Belongs to the actin family. (223 aa)
TSG101Uncharacterized protein. (391 aa)
NDUFB7NADH:ubiquinone oxidoreductase subunit B7. (137 aa)
GLB1Beta-galactosidase. (646 aa)
TAGLNTransgelin; Belongs to the calponin family. (201 aa)
PPARGC1ARRM domain-containing protein. (797 aa)
TTNUncharacterized protein. (2149 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1943 aa)
ALBSerum albumin. (608 aa)
COL12A1Collagen type XII alpha 1 chain. (3046 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
TNNI3Uncharacterized protein. (228 aa)
COL24A1Collagen type XXIV alpha 1 chain. (1708 aa)
TNNT2Troponin T2, cardiac type. (267 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
MMP13Matrix metallopeptidase 13. (472 aa)
COL1A1Collagen type I alpha 1 chain. (1463 aa)
FBN1Fibrillin 1. (2860 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1955 aa)
LOC108633295ZZ-type domain-containing protein. (323 aa)
PLA2G2APhospholipase A(2). (144 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (974 aa)
Your Current Organism:
Capra hircus
NCBI taxonomy Id: 9925
Other names: African dwarf goat, African dwarf goats, C. hircus, Capra aegagrus hircus, domestic goat, goat, goats
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.